Original Article

Anti-inflammatory effect of bacillus subtilis neutral protease

Zhong-da Zhou, Ping Wang, Xiao-lin Zhou


A neutral peptidase was isolated from Bacillus subtilis (A.S. 1. 398). Intraduodenal injection of this protease 40 mg/kg showed a significant anti-inflammatory effect on acute egg albumin-induced edema of hind paws in rats and a weak fibrinolytic activity (60 Vg/ml) in vitro. The [l25I]protease by intraduodenal injection was absorbable from small intestine. Acute ip LD50 in mice was 45 (95% fiducial limits 27 and 55) mg/kg. Hence this protease has a low toxicity. strong anti-inflammatory effect.

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