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Acta Pharmacologica Sinica招聘科学编辑

Acta Pharmacologica Sinica（《中国药理学报》）是由中国药理学会和中国科学院上海药物研究所主办，中国科协主管的英文学术期刊。因工作需要，现招聘全职科学编辑1名，具体要求如下：

负责日常稿件的按时评估和编辑加工
参加学术会议，拜访有关专家和实验室，挖掘优质稿源
参与专题策划和落实
参与宣传和推广，有微信公众号维护经验者优先考虑

Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy – an illustration with firsthand examples

Nanotechnology has been applied extensively in drug delivery to improve the therapeutic outcomes of various diseases. Tremendous efforts have been focused on the development of novel nanoparticles and delineation of the physicochemical properties of nanoparticles in relation to their biological fate and functions. However, in the design and evaluation of these nanotechnology-based drug delivery systems, ...

Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases

Roles of sphingosylphosphorylcholine (SPC) in blood vessels. In normal vessels, the endothelium is intact. SPC acts on endothelial cellsand has protective effects on blood vessels. When the endothelium is injured, vascular smooth muscle cells (VSMCs) are exposed to SPC,which is harmful to blood vessels

Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

Diabetes mellitus is currently a major public health problem. A common complication of diabetes is cardiac dysfunction, which is recognized as a microvascular disease that leads to morbidity and mortality in diabetic patients. While ischemic events are commonly observed in diabetic patients, the risk for developing heart failure is also increased, independent of the severity of coronary artery disease and hypertension. This diabetes-associated clinical entity is considered a distinct disease process referred to as “diabetic cardiomyopathy” ...

Discovery and development of NA-1 for the treatment of acute ischemic stroke

Stroke creates a complex interplay of multiple signaing pathways including excitotoxicity, ionic imbalance, inflammation, oxidative stress and apoptosis. There are very few treatments that have been shown to be beneficial in acute stroke. Recent findings have provided insights into the pathophysiology and mechanisms of ischemic stroke, complementing the traditional glutamate hypothesis: the molecular interaction between PSD95 and GluN2B has been identified as a culprit in stroke-mediated excitotoxicity, leading to the discovery of NA-1, a peptide that disrupts that interaction, as a potent neuroprotective agent for the treatment of acute stroke. ...

Therapeutic gene editing: delivery and regulatory perspectives

Gene-editing technology is an emerging therapeutic modality for manipulating the eukaryotic genome by using target-sequence- speci c engineered nucleases. Because of the exceptional advantages that gene-editing technology offers in facilitating the accurate correction of sequences in a genome, gene editing-based therapy is being aggressively developed as a next-generation therapeutic approach to treat a wide range of diseases.

Programmable co-delivery of the immune checkpoint inhibitor NLG919 and chemotherapeutic doxorubicin via a redox-responsive immunostimulatory polymeric prodrug carrier

To achieve synergistic therapeutic ef cacy and prevent cancer relapse, chemotherapy and immunotherapy have been combined asa new modality for tumor treatment. In this work, we designed a redox-responsive immunostimulatory polymeric prodrug carrier, PSSN10, for programmable co-delivery of an immune checkpoint inhibitor NLG919 (NLG) and a chemotherapeutic doxorubicin (DOX).

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Vol 40, No 2 (February, 2019)

CN 31-1347/R
ISSN 1671-4083
EISSN 1745-7254

2017 Impact Factor 3.562*
53/171 Chemistry, Multidisciplinary
63/261 Pharmacology & Pharmacy

Editor-in-Chief:
Jian Ding

*2018 Journal Citation Reports® Science Edition

Society Resources

Publishing Information

Acta Pharmacologica Sinica is published by SPRINGER NATURE

Membership

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Review Article

Biomarkers for individualized dosage adjustments in immunosuppressive therapy using calcineurin inhibitors after organ transplantation

Rao Fu, Soichiro Tajima, Kimitaka Suetsugu, Hiroyuki Watanabe, Nobuaki Egashira, Satohiro Masuda

Article

A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo

Hong-xuan Feng, Chun-pu Li, Shuang-jie Shu, Hong Liu, Hai-yan Zhang

Naloxone attenuates ischemic brain injury in rats through suppressing the NIK/IKKα/NF-κB and neuronal apoptotic pathways

Xuan Wang, Zu-jun Sun, Jun-lu Wu, Wen-qiang Quan, Wei-dong Xiao, Helen Chew, Cui-min Jiang, Dong Li

NADPH ameliorates MPTP-induced dopaminergic neurodegeneration through inhibiting p38MAPK activation

Jing-si Zhou, Zhou Zhu, Feng Wu, Ying Zhou, Rui Sheng, Jun-chao Wu, Zheng-hong Qin

Ginkgo biloba extracts prevent aortic rupture in angiotensin II-infused hypercholesterolemic mice

Xiao-fang Huang, Song-zhao Zhang, Ya-yu You, Na Zhang, Hong Lu, Alan Daugherty, Xiao-jie Xie

Pharmacological actions of miltirone in the modulation of platelet function

Wei Song, Yuan-yuan Ma, Shuo Miao, Ru-ping Yang, Ying Zhu, Dan Shu, Meng Lu, Rong Ma, Zhang-yin Ming

Plasma miR-142 predicts major adverse cardiovascular events as an intermediate biomarker of dual antiplatelet therapy

Qian-jie Tang, He-ping Lei, Hong Wu, Ji-yan Chen, Chun-yu Deng, Wang-sheng Sheng, Yong-heng Fu, Xiao-hong Li, Yu-bi Lin, Ya-ling Han, Shi-long Zhong

Metabolic perturbations of post-load hyperglycemia vs. fasting hyperglycemia

Jing-yi Lu, Jia-hui Peng, Xiao-jing Ma, Yi-nan Zhang, Wei Zhu, Xing-xing He, Ling-wen Ying, Yu-qian Bao, Jian Zhou, Wei-ping Jia

Varacin-1, a novel analog of varacin C, induces p53- independent apoptosis in cancer cells through ROS-mediated reduction of XIAP

Jing Zhou, Wen-li Li, Zi-xuan Wang, Nai-yuan Chen, Yue Tang, Xiao-xiao Hu, Jing-huan Deng, Yixin Lu, Guo-dong Lu

Annonaceous acetogenin mimic AA005 suppresses human colon cancer cell growth in vivo through downregulation of Mcl-1

Bing Han, Yu-xia Cao, Zhan-ming Li, Zhao-xia Wu, Yu-qin Mao, Hui-ling Chen, Zhu-jun Yao, Li-shun Wang

Antitumor effect of axitinib combined with dopamine and PKPD modeling in the treatment of human breast cancer xenograft

Yuan-heng Ma, Si-yuan Wang, Yu-peng Ren, Jian Li, Ting-jie Guo, Wei Lu, Tian-yan Zhou

Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers

Qing-rou Li, Hui Zhao, Xue-sai Zhang, Henk Lang, Ker Yu

Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pathway inhibitors in BRAF-mutant melanoma

Ming-zhao Gao, Hong-bin Wang, Xiang-ling Chen, Wen-ting Cao, Li Fu, Yun Li, Hai-tian Quan, Cheng-ying Xie, Li-guang Lou

Identification of predominant GNPTAB gene mutations in Eastern Chinese patients with mucolipidosis II/III and a prenatal diagnosis of mucolipidosis II

Yu Wang, Jun Ye, Wen-juan Qiu, Lian-shu Han, Xiao-lan Gao, Li-li Liang, Xue-fan Gu, Hui-wen Zhang

Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration

Meng Liu, Jie Yuan, Wen-juan Hu, Chang-qiang Ke, Yi-fan Zhang, Yang Ye, Da-fang Zhong, Guang-rong Zhao, Sheng Yao, Jia Liu

Below are the latest Acta Pharmacologica Sinica articles published online ahead of print publication.

Editorial

Cannabis, cannabinoid receptors, and endocannabinoid system: yesterday, today, and tomorrow

Jie Wu

Review Article

GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol

Alyssa S. Laun, Sarah H. Shrader, Kevin J. Brown, Zhao-Hui Song

Brain activity of anandamide: a rewarding bliss?

Maria Scherma, Paolo Masia, Valentina Satta, Walter Fratta, Paola Fadda, Gianluigi Tanda

Translational potential of allosteric modulators targeting the cannabinoid CB₁ receptor

Dai Lu, Sri Sujana Immadi, Zhixing Wu, Debra A. Kendall

Integrating endocannabinoid signaling in the regulation of anxiety and depression

An-qi Yin, Feng Wang, Xia Zhang

Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies

Matthew E. Sloan, Caroline W. Grant, Joshua L. Gowin, Vijay A. Ramchandani, Bernard Le Foll

Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system

Ruiqing Ni, Linjing Mu, Simon Ametamey

Article

Cannabidiol does not display drug abuse potential in mice behavior

Adrián Viudez-Martínez, María S. García-Gutiérrez, Juan Medrano-Relinque, Carmen M. Navarrón, Francisco Navarrete, Jorge Manzanares

Cannabinoid CB₁ receptor neutral antagonist AM4113 inhibits heroin self-administration without depressive side effects in rats

Xiang-hu He, Chloe J. Jordan, Kiran Vemuri, Guo-hua Bi, Jia Zhan, Eliot L. Gardner, Alexandros Makriyannis, Yan-lin Wang, Zheng-xiong Xi

Computational systems pharmacology analysis of cannabidiol: a combination of chemogenomics-knowledgebase network analysis and integrated in silico modeling and simulation

Yue-min Bian, Xi-bing He, Yan-kang Jing, Li-rong Wang, Jun-mei Wang, Xiang-Qun Xie

Identification of novel mouse and rat CB1R isoforms and in silico modeling of human CB1R for peripheral cannabinoid therapeutics

Qing-Rong Liu, Nicholas S. Huang, Hong Qu, Jennifer F. O’Connell, Isabel Gonzalez-Mariscal, Sara Santa-Cruz-Calvo, Maire E. Doyle, Zheng-Xiong. Xi, Yun Wang, Emmanuel. S. Onaivi, Josephine M. Egan

CB₂ receptor antibody signal specificity: correlations with the use of partial CB₂-knockout mice and anti-rat CB₂ receptor antibodies

Hai-ying Zhang, Hui Shen, Chloe J. Jordan, Qing-rong Liu, Eliot L. Gardner, Antonello Bonci, Zheng-xiong Xi

Heterogeneity of cannabinoid ligand-induced modulations in intracellular Ca₂₊ signals of mouse pancreatic acinar cells in vitro

Kun-kun Xia, Jian-xin Shen, Ze-bing Huang, Hui-min Song, Ming Gao, De-jie Chen, Shui-jun Zhang, Jie Wu

Developmental and behavioral effects in neonatal and adult mice following prenatal activation of endocannabinoid receptors by capsaicin

Alex Perchuk, Sonya M. Bierbower, Ana Canseco-Alba, Zoila Mora, Lauren Tyrell, Neal Joshi, Norman Schanz, Georgianna G. Gould, Emmanuel S. Onaivi

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