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New Impact Factor of APS rose to 4.010

The new Impact Factor of Acta Pharmacologica Sinica (APS) is 4.010 and the Total Cites is 8687 according to the Journal Citation Reports released June 20 by Clarivate Analytics. The Impact Factor ranking of APS has been promoted to a new record in the Pharmacology & Pharmacy journals (53rd/267, Q1) and the Multidisciplinary Chemistry journals (49th/172, Q2).

Under the leadership of the Editor-in-Chief Professor Jian Ding and the kind support from the Editorial Board members, APS achieved a great success in the journal developments. The steady growth of the impact factor demonstrates the increased recognition of APS in the field. ...

Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy – an illustration with firsthand examples

Nanotechnology has been applied extensively in drug delivery to improve the therapeutic outcomes of various diseases. Tremendous efforts have been focused on the development of novel nanoparticles and delineation of the physicochemical properties of nanoparticles in relation to their biological fate and functions. However, in the design and evaluation of these nanotechnology-based drug delivery systems, ...

Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases

Roles of sphingosylphosphorylcholine (SPC) in blood vessels. In normal vessels, the endothelium is intact. SPC acts on endothelial cellsand has protective effects on blood vessels. When the endothelium is injured, vascular smooth muscle cells (VSMCs) are exposed to SPC,which is harmful to blood vessels

Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

Diabetes mellitus is currently a major public health problem. A common complication of diabetes is cardiac dysfunction, which is recognized as a microvascular disease that leads to morbidity and mortality in diabetic patients. While ischemic events are commonly observed in diabetic patients, the risk for developing heart failure is also increased, independent of the severity of coronary artery disease and hypertension. This diabetes-associated clinical entity is considered a distinct disease process referred to as “diabetic cardiomyopathy” ...

Discovery and development of NA-1 for the treatment of acute ischemic stroke

Stroke creates a complex interplay of multiple signaing pathways including excitotoxicity, ionic imbalance, inflammation, oxidative stress and apoptosis. There are very few treatments that have been shown to be beneficial in acute stroke. Recent findings have provided insights into the pathophysiology and mechanisms of ischemic stroke, complementing the traditional glutamate hypothesis: the molecular interaction between PSD95 and GluN2B has been identified as a culprit in stroke-mediated excitotoxicity, leading to the discovery of NA-1, a peptide that disrupts that interaction, as a potent neuroprotective agent for the treatment of acute stroke. ...

Therapeutic gene editing: delivery and regulatory perspectives

Gene-editing technology is an emerging therapeutic modality for manipulating the eukaryotic genome by using target-sequence- speci c engineered nucleases. Because of the exceptional advantages that gene-editing technology offers in facilitating the accurate correction of sequences in a genome, gene editing-based therapy is being aggressively developed as a next-generation therapeutic approach to treat a wide range of diseases.

Programmable co-delivery of the immune checkpoint inhibitor NLG919 and chemotherapeutic doxorubicin via a redox-responsive immunostimulatory polymeric prodrug carrier

To achieve synergistic therapeutic ef cacy and prevent cancer relapse, chemotherapy and immunotherapy have been combined asa new modality for tumor treatment. In this work, we designed a redox-responsive immunostimulatory polymeric prodrug carrier, PSSN10, for programmable co-delivery of an immune checkpoint inhibitor NLG919 (NLG) and a chemotherapeutic doxorubicin (DOX).

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Vol 41, No 4 (April, 2020)

CN 31-1347/R
ISSN 1671-4083
EISSN 1745-7254

Editor-in-Chief

Jian Ding

2018 Impact Factor 4.010*
49/172 Chemistry, Multidisciplinary
53/267 Pharmacology & Pharmacy

*2019 Journal Citation Reports® Science Edition

Society Resources

Publishing Information

Acta Pharmacologica Sinica is published by SPRINGER NATURE

Membership

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Editorial

Emerging novel approaches to drug research and diagnosis of Parkinson’s disease

Xue-chu Zhen, Hong-Yuan Chu

Review Article

Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration

Jochen H M Prehn, Elisabeth Jirström

Synaptic and cellular plasticity in Parkinson’s disease

Hong-Yuan Chu

Targeting the cholinergic system in Parkinson’s disease

Changliang Liu

Psychosis in Parkinson’s disease and parkinsonism in antipsychotic-naive schizophrenia spectrum psychosis: clinical, nosological and pathobiological challenges

John L. Waddington

Recent advances in dopaminergic strategies for the treatment of Parkinson’s disease

Qi Mao, Wang-zhi Qin, Ao Zhang, Na Ye

Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein

Ming-ming Xu, Philip Ryan, Santosh Rudrawar, Ronald J Quinn, Hai-yan Zhang, George D Mellick

Article

Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson’s disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin

Chen-hong Guo, Ting Cao, Long-tai Zheng, John L Waddington, Xue-chu Zhen

Neuroprotective effects of olanzapine against rotenone-induced toxicity in PC12 cells

Ya-jie Xiong, Yun-zhen Song, Ying Zhu, Wen-qing Zuo, Yi-fan Zhao, Xiao Shen, Wen-juan Wang, Ya-li Liu, Jun-chao Wu, Zhong-qin Liang

Ganoderic acid A protects neural cells against NO stress injury in vitro via stimulating β adrenergic receptors

Zi-ru Yu, Wei-hua Jia, Chao Liu, Hong-qing Wang, Hai-guang Yang, Guo-rong He, Ruo-yun Chen, Guan-hua Du

Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization

Jia-qi Liu, Ming Zhao, Zhao Zhang, Li-yuan Cui, Xin Zhou, Wei Zhang, Shi-feng Chu, Da-yong Zhang, Nai-hong Chen

Cardiovascular Pharmacology

Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway

Jiang Zhu, Yi-fei Wang, Xiao-ming Chai, Ke Qian, Ling-wei Zhang, Peng Peng, Pei-min Chen, Jian-fang Cao, Zheng-hong Qin, Rui Sheng, Hong Xie

Urotensin II and urantide exert opposite effects on the cellular components of atherosclerotic plaque in hypercholesterolemic rabbits

Qing-qing Yu, Da-xin Cheng, Li-ran Xu, Yan-kui Li, Xiao-ya Zheng, Yi Liu, Ya-feng Li, Hao-le Liu, Liang Bai, Rong Wang, Jiang-lin Fan, En-qi Liu, Si-hai Zhao

Hepatic, Gastrointestinal, Pulmonary and Renal Pharmacology

Serum biomarkers combined with ultrasonography for early diagnosis of non-alcoholic fatty liver disease conﬁrmed by magnetic resonance spectroscopy

Ling-ling Qian, Liang Wu, Lei Zhang, Jing Zhang, Jia Zhou, Yue-hua Li, Qi-chen Fang, Hua-ting Li, Wei-ping Jia

Prostaglandin E1 attenuates high glucose-induced apoptosis in proximal renal tubular cells by inhibiting the JNK/Bim pathway

Yu-han Zhang, Ya-qin Zhang, Cong-cong Guo, Li-kang Wang, Yu-jiao Cui, Jian-jun Dong, Lin Liao

Drug Absorption, Distribution, Metabolism and Excretion

Comparative strategies for stem cell biodistribution in a preclinical study

Fang Wang, Zhe Wang, Fen Wang, Kelly Dong, Jing Zhang, Yun-juan Sun, Chun-feng Liu, Mei-jie Xing, Xue Cheng, Su Wei, Jia-wei Zheng, Xiong-fei Zhao, Xiao-ming Wang, Jie Fu, Hai-feng Song

Author Correction

Author Correction: Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice

Wei Yan, Ting-yu Wang, Qi-ming Fan, Lin Du, Jia-ke Xu, Zan-jing Zhai, Hao-wei Li, Ting-ting Tang

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New Impact Factor of APS rose to 4.010

Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy – an illustration with firsthand examples

Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases

Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

Discovery and development of NA-1 for the treatment of acute ischemic stroke

Therapeutic gene editing: delivery and regulatory perspectives

Programmable co-delivery of the immune checkpoint inhibitor NLG919 and chemotherapeutic doxorubicin via a redox-responsive immunostimulatory polymeric prodrug carrier

Society Resources

Publishing Information

Membership

Editorial

Emerging novel approaches to drug research and diagnosis of Parkinson’s disease

Review Article

Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration

Synaptic and cellular plasticity in Parkinson’s disease

Targeting the cholinergic system in Parkinson’s disease

Psychosis in Parkinson’s disease and parkinsonism in antipsychotic-naive schizophrenia spectrum psychosis: clinical, nosological and pathobiological challenges

Recent advances in dopaminergic strategies for the treatment of Parkinson’s disease

Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein

Article

Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson’s disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin

Neuroprotective effects of olanzapine against rotenone-induced toxicity in PC12 cells

Ganoderic acid A protects neural cells against NO stress injury in vitro via stimulating β adrenergic receptors

Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization

Cardiovascular Pharmacology

Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway

Urotensin II and urantide exert opposite effects on the cellular components of atherosclerotic plaque in hypercholesterolemic rabbits

Hepatic, Gastrointestinal, Pulmonary and Renal Pharmacology

Serum biomarkers combined with ultrasonography for early diagnosis of non-alcoholic fatty liver disease conﬁrmed by magnetic resonance spectroscopy

Prostaglandin E1 attenuates high glucose-induced apoptosis in proximal renal tubular cells by inhibiting the JNK/Bim pathway

Drug Absorption, Distribution, Metabolism and Excretion

Comparative strategies for stem cell biodistribution in a preclinical study

Author Correction

Author Correction: Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice

Announcements more

New Impact Factor of APS rose to 4.010

2018 APS Outstanding Contribution Awards

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