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Acta Pharmacologica Sinica招聘科学编辑

Acta Pharmacologica Sinica（《中国药理学报》）是由中国药理学会和中国科学院上海药物研究所主办，中国科协主管的英文学术期刊。因工作需要，现招聘全职科学编辑1名，具体要求如下：

负责日常稿件的按时评估和编辑加工
参加学术会议，拜访有关专家和实验室，挖掘优质稿源
参与专题策划和落实
参与宣传和推广，有微信公众号维护经验者优先考虑

Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy – an illustration with firsthand examples

Nanotechnology has been applied extensively in drug delivery to improve the therapeutic outcomes of various diseases. Tremendous efforts have been focused on the development of novel nanoparticles and delineation of the physicochemical properties of nanoparticles in relation to their biological fate and functions. However, in the design and evaluation of these nanotechnology-based drug delivery systems, ...

Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases

Roles of sphingosylphosphorylcholine (SPC) in blood vessels. In normal vessels, the endothelium is intact. SPC acts on endothelial cellsand has protective effects on blood vessels. When the endothelium is injured, vascular smooth muscle cells (VSMCs) are exposed to SPC,which is harmful to blood vessels

Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

Diabetes mellitus is currently a major public health problem. A common complication of diabetes is cardiac dysfunction, which is recognized as a microvascular disease that leads to morbidity and mortality in diabetic patients. While ischemic events are commonly observed in diabetic patients, the risk for developing heart failure is also increased, independent of the severity of coronary artery disease and hypertension. This diabetes-associated clinical entity is considered a distinct disease process referred to as “diabetic cardiomyopathy” ...

Discovery and development of NA-1 for the treatment of acute ischemic stroke

Stroke creates a complex interplay of multiple signaing pathways including excitotoxicity, ionic imbalance, inflammation, oxidative stress and apoptosis. There are very few treatments that have been shown to be beneficial in acute stroke. Recent findings have provided insights into the pathophysiology and mechanisms of ischemic stroke, complementing the traditional glutamate hypothesis: the molecular interaction between PSD95 and GluN2B has been identified as a culprit in stroke-mediated excitotoxicity, leading to the discovery of NA-1, a peptide that disrupts that interaction, as a potent neuroprotective agent for the treatment of acute stroke. ...

Therapeutic gene editing: delivery and regulatory perspectives

Gene-editing technology is an emerging therapeutic modality for manipulating the eukaryotic genome by using target-sequence- speci c engineered nucleases. Because of the exceptional advantages that gene-editing technology offers in facilitating the accurate correction of sequences in a genome, gene editing-based therapy is being aggressively developed as a next-generation therapeutic approach to treat a wide range of diseases.

Programmable co-delivery of the immune checkpoint inhibitor NLG919 and chemotherapeutic doxorubicin via a redox-responsive immunostimulatory polymeric prodrug carrier

To achieve synergistic therapeutic ef cacy and prevent cancer relapse, chemotherapy and immunotherapy have been combined asa new modality for tumor treatment. In this work, we designed a redox-responsive immunostimulatory polymeric prodrug carrier, PSSN10, for programmable co-delivery of an immune checkpoint inhibitor NLG919 (NLG) and a chemotherapeutic doxorubicin (DOX).

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Vol 40, No 4 (April, 2019)

CN 31-1347/R
ISSN 1671-4083
EISSN 1745-7254

2017 Impact Factor 3.562*
53/171 Chemistry, Multidisciplinary
63/261 Pharmacology & Pharmacy

Editor-in-Chief:
Jian Ding

*2018 Journal Citation Reports® Science Edition

Society Resources

Publishing Information

Acta Pharmacologica Sinica is published by SPRINGER NATURE

Membership

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Article

CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses

Dan-dan Liu, Xia Yuan, Shi-feng Chu, Chen Chen, Qian Ren, Piao Luo, Mei-yu Lin, Sha-sha Wang, Tian-bi Zhu, Qi-di Ai, Ying-da Zang, Dong-ming Zhang, Xin He, Zhi-hua Huang, Hong-shuo Sun, Zhong-ping Feng, Nai-hong Chen

Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis

Zhi-li Ren, Chao-dong Wang, Tao Wang, Hui Ding, Ming Zhou, Nan Yang, Yan-yong Liu, Piu Chan

Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels

Yan-fen Li, Yue-ming Zheng, Yong Yu, Yong Gan, Zhao-bing Gao

Specific activation of mGlu2 induced IGF-1R transactivation in vitro through FAK phosphorylation

Yong-jian Hu, Qian Sun, Wen-hua Zhang, Yu-jia Huo, Chan-juan Xu, Jian-feng Liu

Platelet microparticles contribute to aortic vascular endothelial injury in diabetes via the mTORC1 pathway

Gui-hua Wang, Kun-ling Ma, Yang Zhang, Ze-bo Hu, Liang Liu, Jian Lu, Pei-pei Chen, Chen-chen Lu, Xiong-zhong Ruan, Bi-cheng Liu

Dysregulation of miR-135a-5p promotes the development of rat pulmonary arterial hypertension in vivo and in vitro

Hong-mei Liu, Yi Jia, Ying-xian Zhang, Jun Yan, Ning Liao, Xiao-hui Li, Yuan Tang

Low serum osteocalcin levels are correlated with left ventricular systolic dysfunction and cardiac death in Chinese men

Xue-li Zhang, Yun Shen, Xiao-jing Ma, Zhi-gang Lu, Yi-ting Xu, Qin Xiong, Yu-qian Bao

Effects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites

Xue Bai, Bin Zhang, Ping Wang, Guan-lei Wang, Jia-li Li, Ding-sheng Wen, Xing-zhen Long, Hong-shuo Sun, Yi-bin Liu, Min Huang, Shi-long Zhong

Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome

Lukas Andreas Heger, Mark Kerber, Marcus Hortmann, Samuel Robinson, Maximilian Mauler, Daniela Stallmann, Daniel Duerschmied, Christoph Bode, Christoph Hehrlein, Ingo Ahrens

Magnesium lithospermate B improves the gut microbiome and bile acid metabolic proﬁles in a mouse model of diabetic nephropathy

Jing Zhao, Qing-li Zhang, Jian-hua Shen, Kai Wang, Jia Liu

Thymopentin-loaded phospholipid-based phase separation gel with long-lasting immunomodulatory effects: in vitro and in vivo studies

Ting Zhang, Xian-yan Qin, Xi Cao, Wen-hao Li, Tao Gong, Zhi-rong Zhang

Silk ﬁbroin peptide suppresses proliferation and induces apoptosis and cell cycle arrest in human lung cancer cells

Mei-sa Wang, Yi-bo Du, Hui-ming Huang, Zhong-ling Zhu, Shuang-shuang Du, Shao-yong Chen, Hong-ping Zhao, Zhao Yan

Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer

Bo-wen Liu, Tian-jiao Wang, Lei-lei Li, Lu Zhang, Yun-xia Liu, Jin-yan Feng, Yue Wu, Fei-fei Xu, Quan-sheng Zhang, Ming-zhu Bao, Wei-ying Zhang, Li-hong Ye

Asiatic acid enhances intratumor delivery and the antitumor effect of pegylated liposomal doxorubicin by reducing tumor-stroma collagen

Luo Fang, Si-si Kong, Li-ke Zhong, Can-ming Wang, Yu-jia Liu, Hai-ying Ding, Jiao Sun, Yi-wen Zhang, Fan-zhu Li, Ping Huang

KLF4 functions as an oncogene in promoting cancer stem cell- like characteristics in osteosarcoma cells

Xiao-tian Qi, Yang-ling Li, Yan-qi Zhang, Tong Xu, Bin Lu, Liang Fang, Jian-qing Gao, Lu-shan Yu, Di-feng Zhu, Bo Yang, Qiao-jun He, Mei-dan Ying

Apatinib, a selective VEGFR2 inhibitor, improves the delivery of chemotherapeutic agents to tumors by normalizing tumor vessels in LoVo colon cancer xenograft mice

Kai Zhou, Jing-wei Zhang, Qi-zhi Wang, Wen-yue Liu, Jia-li Liu, Lan Yao, Ming-min Cai, Sui-ying Ni, Qing-yun Cai, Guang-ji Wang, Fang Zhou

Molecular binding mode of PF-232798, a clinical anti-HIV candidate, at chemokine receptor CCR5

Ya Zhu, Yan-long Zhao, Jian Li, Hong Liu, Qiang Zhao, Bei-li Wu, Zhen-lin Yang

Letter to the Editor

Increased risk for cerebral ischemic stroke in diabetes: genetically polymorphic CYP mediated production of neuroprotective EETs and sulfonylurea metabolism in relation with KATP channels

Umit Yasar, Melih O. Babaoglu

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Acta Pharmacologica Sinica招聘科学编辑

Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy – an illustration with firsthand examples

Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases

Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

Discovery and development of NA-1 for the treatment of acute ischemic stroke

Therapeutic gene editing: delivery and regulatory perspectives

Programmable co-delivery of the immune checkpoint inhibitor NLG919 and chemotherapeutic doxorubicin via a redox-responsive immunostimulatory polymeric prodrug carrier

Society Resources

Publishing Information

Membership

Article

CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses

Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis

Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels

Specific activation of mGlu2 induced IGF-1R transactivation in vitro through FAK phosphorylation

Platelet microparticles contribute to aortic vascular endothelial injury in diabetes via the mTORC1 pathway

Dysregulation of miR-135a-5p promotes the development of rat pulmonary arterial hypertension in vivo and in vitro

Low serum osteocalcin levels are correlated with left ventricular systolic dysfunction and cardiac death in Chinese men

Effects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites

Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome

Magnesium lithospermate B improves the gut microbiome and bile acid metabolic proﬁles in a mouse model of diabetic nephropathy

Thymopentin-loaded phospholipid-based phase separation gel with long-lasting immunomodulatory effects: in vitro and in vivo studies

Silk ﬁbroin peptide suppresses proliferation and induces apoptosis and cell cycle arrest in human lung cancer cells

Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer

Asiatic acid enhances intratumor delivery and the antitumor effect of pegylated liposomal doxorubicin by reducing tumor-stroma collagen

KLF4 functions as an oncogene in promoting cancer stem cell- like characteristics in osteosarcoma cells

Apatinib, a selective VEGFR2 inhibitor, improves the delivery of chemotherapeutic agents to tumors by normalizing tumor vessels in LoVo colon cancer xenograft mice

Molecular binding mode of PF-232798, a clinical anti-HIV candidate, at chemokine receptor CCR5

Letter to the Editor

Increased risk for cerebral ischemic stroke in diabetes: genetically polymorphic CYP mediated production of neuroprotective EETs and sulfonylurea metabolism in relation with KATP channels

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2018 APS Outstanding Contribution Awards

Acta Pharmacologica Sinica招聘科学编辑

2017 APS Outstanding Contribution Awards