Vol 47, No 1 (January 2026): Acta Pharmacologica Sinica

Perspective

AI-driven breakthroughs in ion channel drug discovery: the future is now   Pages (1-2)
Ming-yue Zheng, Zhao-bing Gao

Review Article

New advances in small molecule drugs targeting NMDA receptors   Pages (3-21)
Yue Zeng, Zhi-yan Qu, Qian-wen Zhu, Hai-ying Wang, Yu Zhou, Zhao-bing Gao

Article

Discovery of selective GluN1/GluN3A NMDA receptor inhibitors using integrated AI and physics-based approaches   Pages (22-31)
Shi-wei Li, Yue Zeng, Sa-nan Wu, Xin-yue Ma, Chao Xu, Zong-quan Li, Sui Fang, Xue-qin Chen, Zhao-bing Gao, Fang Bai
Identification of small-molecule inhibitors for GluN1/GluN3A NMDA receptors via a multiscale CNN-based prediction model   Pages (32-40)
Li Han, Yue Zeng, Zhi-yan Qu, Sui Fang, Hai-ying Wang, Ya-shuo Dong, Xiang-ming Zeng, Tong-yan Zhang, Ze-bin Yu, Ling Kang, Zhao-bing Gao, Quan Guo
AI-enhanced virtual screening approach to hit identification for GluN1/GluN3A NMDA receptor   Pages (41-52)
Yue-shan Ji, Yue Zeng, Shao-fei Hu, Shu-wang Li, Bei-chen Zhang, Chang Liu, Hao-chen Wu, An-yang Wang, Zhao-bing Gao, Yue Kong
GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating   Pages (53-68) Open
Yuan-ping Dong, Yun Wu, Yi-lu Zhao, Yu-min Chen, Tong-ye Liu, Yi-he Zhang, Jie-ying Xie, Jin-feng Zhang, Han Zhang, He Chen, Yu Peng, Chun-lei Zhang, Andrew R. Rau, Kasper B. Hansen, Hai-bing Xu, Feng Yi
NADPH acts as an endogenous P2X7 receptor modulator to gate neuroinflammatory responses of microglia   Pages (69-85)
Yu-jie Mou, Feng-min Li, Jun-tong Lou, Hai-yue Tu, Yi Zhu, Rui Sheng, Zhong-ling Zhang, Yu-zheng Zhao, Fu-hai Ji, Jun-chao Wu, Zheng-hong Qin
circSP199a, a circularized RNA sponge targeting miR-199a-5p and -3p, mitigates mouse cardiac hypertrophy and fibrosis   Pages (86-102)
Hua-yan Wu, Chuan-meng Zhou, Yuan Gao, Yi-hong Wen, Ya-ting Hu, Heng-li Zhao, Wen-yan Dong, Xiao-yao Liu, Lin Zhai, Yi Li, Meng-zhen Zhang, Jie-ning Zhu, Hui Li, Jin-dong Xu, Ning Ma, Yu-peng Liu, Xi-long Zheng, Xian-hong Fang, Zhi-xin Shan
Sirtuin 6 mitigates thoracic aortic aneurysm progression via maintenance of mitochondria homeostasis in vascular smooth muscle cells   Pages (103-118)
Xiao-ting Yu, Nan Zhao, Yu-tao Ma, Jin-meng Jia, Yan-ting Song, Xiao-yan Liu, Yao Xiao, Bo Jia, Guang-ming Li, Jin-han He, Sheng Wang, Jun-ming Zhu, Frank J. Gonzalez, Ai-juan Qu
Betaine-homocysteine methyltransferase protects against acetaminophen-induced acute liver failure via BACH1-SCD1-oleic acid axis   Pages (119-134)
Yu-ting Zhang, Xiao-ming Yang, Quan-shan Jin, Jia-yi Chen, Nan-bin Zhu, Yi Ju, Zi-yan Lin, Yang Zhi, Yi-nuo Dong, Chun-min Li, Yi-min Mao, Xiu-ling Zhi, Ming-yang Ma, Ya-li Xu, Xiao-bo Li
PDE4 inhibitor apremilast ameliorates TNBS-induced irritable bowel syndrome in mice by activating the Nrf-2 signaling pathway in enteric glial cells   Pages (135-147)
Yu-hao Lu, Shu-yue Lei, Tao Yang, You-sheng Xu, Hong-lin Wang, Chun-lan Feng, Wei Tang
GRK2 dysfunction mediates acute kidney injury in murine administered methotrexate combined with omeprazole   Pages (148-161)
Xiao Wei, Jun Yu, Jin-zhang Gao, Zheng-kun Xu, Xiao Jiang, Wen-wen Shen, Chun Wang, Yong-gui Wu
Structural and mechanistic insights into dual activation of cagrilintide in amylin and calcitonin receptors   Pages (162-172)
Yi-min Gu, Qing-ning Yuan, Xin Li, Qian He, H. Eric Xu, Li-hua Zhao
Salvianolic acid A from Salvia miltiorrhiza identified as a cap-dependent endonuclease inhibitor for pathogenic arenaviruses   Pages (173-185) Open
Xiao Gao, Yan Wu, Xiao-xue He, Guo-long Liu, Hai-xia Yang, Jia Lu, Xue-rui Zhu, Xin-lan Chen, Chen-shu Zhao, Hao-yu Li, Zhong-fa Zhang, Chan Yang, Shu Shen, Fei Deng, Wei Xu, Shu-wen Liu, Geng-fu Xiao, Xiao-yan Pan
Decoding ligand recognition and constitutive activation of histamine H3 and H4 receptors   Pages (186-196)
San-shan Jin, Heng Zhang, Jia-hui Yan, Can-rong Wu, Xiao-qing Cai, Kai Wu, Ming-Wei Wang, H. Eric Xu, De-hua Yang, Yi Jiang
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity   Pages (197-208) Open
Yao Tu, Qing-yun Zhu, Wen-jun Huang, Sha Feng, Yu-ling Tan, Lu-lu Li, Xin-tong Xie, Qin-yuan Li, Shou-hui Huang, Cheng-zhou Mao, Bi-zhu Chu, Yu-yang Jiang
ALKBH5 deficiency suppresses hepatocarcinogenesis in mice via m6A-dependent STAT1 restoration   Pages (209-221)
Kai-ting Wang, Shuai Yang, Zi-han Zhao, Chun-hua Rui, Si-yun Shen, Dan Cao, Lin-na Guo, Shan-hua Tang, Lei Chen, Hong-yang Wang, Xin-yao Qiu
Tigecycline suppresses colon cancer stem cells and impairs tumor engraftment by targeting SNAI1-regulated epithelial-mesenchymal transition   Pages (222-241)
Antonio Jesús Ruiz-Malagón, María Jesús Rodríguez-Sojo, Jorge García-García, Ailec Ho-Plagaro, Federico García, Teresa Vezza, Eduardo Redondo-Cerezo, Carmen Griñán-Lisón, Juan Antonio Marchal, María Elena Rodríguez-Cabezas, Alba Rodríguez-Nogales, Julio Gálvez
Isoliensinine inhibits mitophagy and sensitizes T cell malignancies for STING-mediated NK clearance   Pages (242-254)
Xiao Ge, Guang-ming Yang, Xiao-long Zhang, Jing Cao, Ying-jie Qing, San-bing Shen, Yang Pan, Po Hu
SOCS1 depletion drives osteosarcoma stemness and chemoresistance by suppressing ACTN4 degradation   Pages (255-271)
Jin-yan Feng, Xian-fu Wei, Long Chen, Hou-zhi Yang, Yi-qin Li, Jin-wu Wang, Yong-heng Liu, Yao Xu, Qing-qian Zhao, Pu Li, Xiao-dong Zhang, Guo-wen Wang, Xiu-xin Han

Editorial Expression of Concern

Editorial Expression of Concern: n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2α and telomerase activity   Pages (272)
Chyou-wei Wei, Chai-ching Lin, Yung-luen Yu, Chai-yi Lin, Po-cheng Lin, Min-tze Wu, Cheng-jueng Chen, Wen-liang Chang, Shinn-zong Lin, Yi-lin Sophia Chen, Horng-jyh Harn