Vol 41, No 6 (June 2020): Acta Pharmacologica Sinica

Article

A comparative pharmacogenomic analysis of three classic TCM prescriptions for coronary heart disease based on molecular network modeling   Pages (735–744)
Ying-ying Zhang, Zi-de Zhao, Peng-yun Kong, Lin Gao, Ya-nan Yu, Jun Liu, Peng-qian Wang, Bing Li, Xiao-xu Zhang, Li-qian Yang, Zhong Wang
Tissue-specific relaxin-2 is differentially associated with the presence/size of an arterial aneurysm and the severity of atherosclerotic disease in humans   Pages (745–752)
Konstantinos Papoutsis, Alkistis Kapelouzou, Georgios Georgiopoulos, Christos Kontogiannis, Christos Kourek, Konstantinos S Mylonas, Nikolaos Patelis, Dennis V Cokkinos, Ioannis Karavokyros, Sotirios Georgopoulos
RGD-hirudin-based low molecular weight peptide prevents blood coagulation via subcutaneous injection   Pages (753–762)
Ya-ran Li, Yi-nong Huang, Bing Zhao, Meng-fang Wu, Tian-yu Li, Yan-ling Zhang, Di Chen, Min Yu, Wei Mo
Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells   Pages (763–770)
Sai-long Zhang, Zhi-yong Li, Dong-sheng Wang, Tian-ying Xu, Mao-bing Fan, Ming-he Cheng, Chao-yu Miao
Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-κB pathway   Pages (771–781)
Qi Liu, Rui Zuo, Kai Wang, Fei-fei Nong, Ya-jun Fu, Shao-wei Huang, Zeng-feng Pan, Yi Zhang, Xia Luo, Xiang-liang Deng, Xiao-xue Zhang, Lian Zhou, Yang Chen
Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease   Pages (782–790)
Jia Meng, Sai-zhen Wang, Jin-zhao He, Shuai Zhu, Bo-yue Huang, Shu-yuan Wang, Min Li, Hong Zhou, Shu-qian Lin, Bao-xue Yang
The hypoglycemic mechanism of catalpol involves increased AMPK-mediated mitochondrial biogenesis   Pages (791–799)
Deng-qiu Xu, Chun-jie Li, Zhen-zhou Jiang, Lu Wang, Hong-fei Huang, Zhi-jian Li, Li-xin Sun, Si-si Fan, Lu-yon Zhang, Tao Wang
IgD-Fc-Ig fusion protein, a new biological agent, inhibits T cell function in CIA rats by inhibiting IgD-IgDR-Lck-NF-κB signaling pathways   Pages (800–812)
Le Han, Xian-zheng Zhang, Chen Wang, Xiao-yu Tang, Yue Zhu, Xiao-yu Cai, Yu-jing Wu, Jin-ling Shu, Qing-tong Wang, Jing-yu Chen, Yan Chang, Hua-xun Wu, Ling-ling Zhang, Wei Wei
Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells   Pages (813–824)
Yi Liu, Ke-xin Zhu, Lei Cao, Zhi-fu Xie, Min Gu, Wei Lü, Jing-ya Li, Fa-jun Nan
Chalcomoracin inhibits cell proliferation and increases sensitivity to radiotherapy in human non-small cell lung cancer cells via inducing endoplasmic reticulum stress-mediated paraptosis   Pages (825–834)
Shi-rong Zhang, Xiao-chen Zhang, Jia-feng Liang, Hong-ming Fang, Hai-xiu Huang, Yan-yan Zhao, Xue-qin Chen, Sheng-lin Ma
A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells   Pages (835–842)
You-you Yan, Ke-yu Shi, Fei Teng, Jing Chen, Jin-xin Che, Xiao-wu Dong, Neng-ming Lin, Bo Zhang
Nimesulide increases the aldehyde oxidase activity of humans and rats   Pages (843–851)
Lei Zhou, Xiao-yan Pang, Xiang-yu Hou, Lu Liu, Zi-tao Guo, Xiao-yan Chen
Physiologically based pharmacokinetic–pharmacodynamic modeling for prediction of vonoprazan pharmacokinetics and its inhibition on gastric acid secretion following intravenous/oral administration to rats, dogs and humans   Pages (852–865)
Wei-min Kong, Bin-bin Sun, Zhong-jian Wang, Xiao-ke Zheng, Kai-jing Zhao, Yang Chen, Jia-xin Zhang, Pei-hua Liu, Liang Zhu, Ru-jun Xu, Ping Li, Li Liu, Xiao-dong Liu
Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin   Pages (866–878)
Lan Yao, Jing-wei Zhang, Bin Chen, Ming-min Cai, Dong Feng, Qi-zhi Wang, Xin-yu Wang, Jian-guo Sun, Yi-wen Zheng, Guang-ji Wang, Fang Zhou