Vol 39, No 11 (November 2018): Acta Pharmacologica Sinica

Review Article

Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity Pages:1693–1698
Jiu-cheng Zhang, Wei-dong Chen, Jean Bustamante Alvarez, Kelly Jia, Lei Shi, Qiang Wang, Ning Zou, Kai He, Hua Zhu
The role of G protein-coupled receptor kinases in the pathology of malignant tumors Pages:1699–1705
Wu-yi Sun, Jing-jing Wu, Wen-ting Peng, Jia-chang Sun, Wei Wei

Article

Berberine attenuates ischemia–reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation Pages:1706–1715
Jun-rong Zhu, Hai-dan Lu, Chao Guo, Wei-rong Fang, Hong-dong Zhao, Jun-shan Zhou, Feng Wang, Yan-li Zhao, Yun-man Li, Ying-dong Zhang, Chang-qing Yang, Jian-guo Sun
Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7 Pages:1716–1724
Xiao-yu Zhang, Rui-yun Bi, Peng Zhang, Ye-hua Gan
ClC-3 promotes angiotensin II-induced reactive oxygen species production in endothelial cells by facilitating Nox2 NADPH oxidase complex formation Pages:1725–1734
Guo-zheng Liang, Li-min Cheng, Xing-feng Chen, Yue-jiao Li, Xiao-long Li, Yong-yuan Guan, Yan-hua Du
Telomere shortening activates TGF-β/Smads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis Pages:1735–1745
Ying-ying Liu, Yao Shi, Ya Liu, Xing-hua Pan, Ke-xiong Zhang
GP205, a new hepatitis C virus NS3/4A protease inhibitor, displays higher metabolic stability in vitro and drug exposure in vivo Pages:1746–1752
Pei-bin Zhai, Jie Qing, Ben Li, Lin-qi Zhang, Lan Ma, Li Chen
Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice Pages:1753–1759
Ali Mahzari, Xiao-Yi Zeng, Xiu Zhou, Songpei Li, Jun Xu, Wen Tan, Ross Vlahos, Stephen Robinson, Ji-Ming YE
Icariin prevents bone loss by inhibiting bone resorption and stabilizing bone biological apatite in a hindlimb suspension rodent model Pages:1760–1767
Jin-peng He, Xiu Feng, Ju-fang Wang, Wen-gui Shi, He Li, Sergei Danilchenko, Aleksei Kalinkevich, Mykhailo Zhovner
Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R Pages:1768–1776
Ying-Qiang Liu, Ya-Nan Wang, Xiao-Yun Lu, Lin-Jiang Tong, Yan Li, Tao Zhang, Qiu-Ju Xun, Fang Feng, Yu-Zhe Chen, Yi Su, Yan-Yan Shen, Yi Chen, Mei-Yu Geng, Ke Ding, Yan-Li Li, Hua Xie, Jian Ding
EGFR-targeting, β-defensin-tailored fusion protein exhibits high therapeutic efficacy against EGFR-expressed human carcinoma via mitochondria-mediated apoptosis Pages:1777–1786
Wen-Juan Liu, Xiu-Jun Liu, Jian Xu, Liang Li, Yi Li, Sheng-Hua Zhang, Jia-Lin Wang, Qing-Fang Miao, Yong-Su Zhen
The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways Pages:1787–1796
Hang Li, Zhen Wang, Mian Jiang, Run-ping Fang, Hui Shi, Yu Shen, Xiao-li Cai, Qian Liu, Kai Ye, Sai-jun Fan, Wei-ying Zhang, Li-hong Ye
HOTAIR lncRNA SNPs rs920778 and rs1899663 are associated with smoking, male gender, and squamous cell carcinoma in a Chinese lung cancer population Pages:1797–1803
Cong Wang, Ying Li, Yong-wen Li, Hong-bing Zhang, Hao Gong, Yin Yuan, Wei-ting Li, Hong-yu Liu, Jun Chen
Isoflavones enhance pharmacokinetic exposure of active lovastatin acid via the upregulation of carboxylesterase in high-fat diet mice after oral administration of Xuezhikang capsules Pages:1804–1815
Dong Feng, Chun Ge, Zhao-yi Tan, Jian-guo Sun, Yuan Xie, Lan Yao, Cai-xia Yan, Ji-ye Aa, Guang-ji Wang
High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds Pages:1816–1822
Jia Wang, Grace Qun Gong, Yan Zhou, Woo-Jeong Lee, Christina Maree Buchanan, William Alexander Denny, Gordon William Rewcastle, Jackie Diane Kendall, James Michael Jeremy Dickson, Jack Urquhart Flanagan, Peter Robin Shepherd, De-Hua Yang, Ming-Wei Wang