Vol 40, No 4 (April 2019): Acta Pharmacologica Sinica

Article

CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses Pages(425–440)
Dan-dan Liu, Xia Yuan, Shi-feng Chu, Chen Chen, Qian Ren, Piao Luo, Mei-yu Lin, Sha-sha Wang, Tian-bi Zhu, Qi-di Ai, Ying-da Zang, Dong-ming Zhang, Xin He, Zhi-hua Huang, Hong-shuo Sun, Zhong-ping Feng, Nai-hong Chen
Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis Pages(441–450)
Zhi-li Ren, Chao-dong Wang, Tao Wang, Hui Ding, Ming Zhou, Nan Yang, Yan-yong Liu, Piu Chan
Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels Pages(451–459)
Yan-fen Li, Yue-ming Zheng, Yong Yu, Yong Gan, Zhao-bing Gao
Specific activation of mGlu2 induced IGF-1R transactivation in vitro through FAK phosphorylation Pages(460–467)
Yong-jian Hu, Qian Sun, Wen-hua Zhang, Yu-jia Huo, Chan-juan Xu, Jian-feng Liu
Platelet microparticles contribute to aortic vascular endothelial injury in diabetes via the mTORC1 pathway Pages(468–476)
Gui-hua Wang, Kun-ling Ma, Yang Zhang, Ze-bo Hu, Liang Liu, Jian Lu, Pei-pei Chen, Chen-chen Lu, Xiong-zhong Ruan, Bi-cheng Liu
Dysregulation of miR-135a-5p promotes the development of rat pulmonary arterial hypertension in vivo and in vitro Pages(477–485)
Hong-mei Liu, Yi Jia, Ying-xian Zhang, Jun Yan, Ning Liao, Xiao-hui Li, Yuan Tang
Low serum osteocalcin levels are correlated with left ventricular systolic dysfunction and cardiac death in Chinese men Pages(486–491)
Xue-li Zhang, Yun Shen, Xiao-jing Ma, Zhi-gang Lu, Yi-ting Xu, Qin Xiong, Yu-qian Bao
Effects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites Pages(492–499)
Xue Bai, Bin Zhang, Ping Wang, Guan-lei Wang, Jia-li Li, Ding-sheng Wen, Xing-zhen Long, Hong-shuo Sun, Yi-bin Liu, Min Huang, Shi-long Zhong
Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome Pages(500–506)
Lukas Andreas Heger, Mark Kerber, Marcus Hortmann, Samuel Robinson, Maximilian Mauler, Daniela Stallmann, Daniel Duerschmied, Christoph Bode, Christoph Hehrlein, Ingo Ahrens
Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy Pages(507–513)
Jing Zhao, Qing-li Zhang, Jian-hua Shen, Kai Wang, Jia Liu
Thymopentin-loaded phospholipid-based phase separation gel with long-lasting immunomodulatory effects: in vitro and in vivo studies Pages(514–521)
Ting Zhang, Xian-yan Qin, Xi Cao, Wen-hao Li, Tao Gong, Zhi-rong Zhang
Silk fibroin peptide suppresses proliferation and induces apoptosis and cell cycle arrest in human lung cancer cells Pages(522–529)
Mei-sa Wang, Yi-bo Du, Hui-ming Huang, Zhong-ling Zhu, Shuang-shuang Du, Shao-yong Chen, Hong-ping Zhao, Zhao Yan
Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer Pages(530–538)
Bo-wen Liu, Tian-jiao Wang, Lei-lei Li, Lu Zhang, Yun-xia Liu, Jin-yan Feng, Yue Wu, Fei-fei Xu, Quan-sheng Zhang, Ming-zhu Bao, Wei-ying Zhang, Li-hong Ye
Asiatic acid enhances intratumor delivery and the antitumor effect of pegylated liposomal doxorubicin by reducing tumor-stroma collagen Pages(539–545)
Luo Fang, Si-si Kong, Li-ke Zhong, Can-ming Wang, Yu-jia Liu, Hai-ying Ding, Jiao Sun, Yi-wen Zhang, Fan-zhu Li, Ping Huang
KLF4 functions as an oncogene in promoting cancer stem cell- like characteristics in osteosarcoma cells Pages(546–555)
Xiao-tian Qi, Yang-ling Li, Yan-qi Zhang, Tong Xu, Bin Lu, Liang Fang, Jian-qing Gao, Lu-shan Yu, Di-feng Zhu, Bo Yang, Qiao-jun He, Mei-dan Ying
Apatinib, a selective VEGFR2 inhibitor, improves the delivery of chemotherapeutic agents to tumors by normalizing tumor vessels in LoVo colon cancer xenograft mice Pages(556–562)
Kai Zhou, Jing-wei Zhang, Qi-zhi Wang, Wen-yue Liu, Jia-li Liu, Lan Yao, Ming-min Cai, Sui-ying Ni, Qing-yun Cai, Guang-ji Wang, Fang Zhou
Molecular binding mode of PF-232798, a clinical anti-HIV candidate, at chemokine receptor CCR5 Pages(563–568)
Ya Zhu, Yan-long Zhao, Jian Li, Hong Liu, Qiang Zhao, Bei-li Wu, Zhen-lin Yang

Letter to the Editor

Increased risk for cerebral ischemic stroke in diabetes: genetically polymorphic CYP mediated production of neuroprotective EETs and sulfonylurea metabolism in relation with KATP channels Pages(569–570)
Umit Yasar, Melih O. Babaoglu