Vol 46, No 11 (November 2025): Acta Pharmacologica Sinica

Review

Advancing active compound discovery for novel drug targets: insights from AI-driven approaches   Pages (2865-2876)
Xing-you Wang, Yang Chen, Yu-fan Li, Chao-yang Wei, Meng-ya Liu, Chen-xing Yuan, Yao-yu Zheng, Mo-han Qin, Yu-feng Sheng, Xiao-chu Tong, Ming-yue Zheng, Xu-tong Li

Review Article

The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis   Pages (2877-2892)
Ying-juan Liu, Guo-rui Jia, Sheng-han Zhang, Yun-liang Guo, Xi-zhen Ma, Hua-min Xu, Jun-xia Xie

Article

NPB-1575 attenuates neuroinflammation and resists ferroptosis in rat ischemic stroke via IRS2 signaling pathway   Pages (2893-2907)
Xin-nan Li, Nian-ying Shang, Meng-yao Liu, Song-yang Sui, Jing-shu Tang, Jia-qi Lan, Yu-ying Kang, Bao-dan Zhang, Zi-peng Wen, Xin-hong Feng, Lei Wu, Jun-gui Dai, Ying Peng
Neuroinflammation leads to pharmacoresistance in temporal lobe epilepsy via promoting spermine degradation   Pages (2908-2923)
Meng-qi Yan, Xiao-yun Qiu, Shuo Zhang, Xue-min Yu, Min-juan Sun, Yuan-zhi Yang, Yi-wei Gong, Shuang Zou, Meng-han Li, Fan Fei, Yu Du, Yi Wang, Ying-ying Tang, Zhong Chen, Ceng-lin Xu
Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1   Pages (2924-2937) Open
Wei Si, Chun-lei Wang, Ling-hua Zeng, Qiao-yue Zhao, Ya-ting Xie, Yang Yang, Hong-tao Diao, Jing-lun Song, Han Wu, Feng Zhang, Zhuo Wang, Xue Kong, Wei-tao Jiang, Xin-yue Zhang, Ke-ying Lin, Fang-ting Yao, Yu-ting Xiong, Teng-fei Pan, Ping Pang, Bao-feng Yang, Yu Bian
YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes   Pages (2938-2950)
Qing-song Zheng, Yong-qiang Xiong, Jia-chen Xu, Jin-fu Qian, Wu Luo, Qin-yan Wang, Yan-ni Zhao, Yue Luo, Ya-qian Cui, Yi Fang, Xiao-chen Guo, Ding-dao Chen, Yi Wang, Guang Liang
SMURF2 inhibition attenuates cardiac hypertrophy through blocking ubiquitination degradation of AXIN1   Pages (2951-2962)
Ying Kang, Yan Zu, Qi-yao Fan, Xia-meng Liu, Shi-qing Chen, Liu-liu Ruan, Xin Tang, Li-ping Xie, Yong Ji
Kv1.3 knockdown attenuates alcohol-related liver injury in mice through induction of tryptamine   Pages (2963-2974)
Hao Wang, Guo-qing Xia, Ting Ke, Xi-xi Chen, Wen-jun Zhen, Yuan-yuan Tian, Shi Chen, Cheng Zhang, Jun Li, Lei Zhang, De-jun Wu, Ye-tao Wang, Liang He, Wen-fang Tian, Bao-ming Wu
Acteoside-containing caffeic acid is bioactive functional group of antifibrotic effect by suppressing inflammation via inhibiting AHR nuclear translocation in chronic kidney disease   Pages (2975-2988)
Yan-ni Wang, Xin Wu, Qi-yan Shan, Qiao Yang, Xiao-yong Yu, Jian-hua Yang, Hua Miao, Gang Cao, Ying-yong Zhao
Structural characterization of the urea transporter bound to the orally bioavailable inhibitor E3   Pages (2989-2997)
Shen-ming Huang, Bo-yang Cai, Lei Liu, Le-jin Yang, Zhi Li, Chao Zhang, Meng-yao Xiong, Hang Zhang, Yan-rong Li, Zhi-zhen Huang, Ying Sun, Bao-xue Yang, Jin-peng Sun
Molecular recognition of two approved drugs Macimorelin and Anamorelin by the growth hormone secretagogue receptor   Pages (2998-3008)
Ruo-lan Wang, Jun Sun, Heng Liu, Shi-meng Guo, Yu Zhang, Wen Hu, Jiang Wang, Hong Liu, You-wen Zhuang, Yi Jiang, Xin Xie, H. Eric Xu, Yue Wang
The conformational epitope of a gp41-specific mucosal protective IgA binds to the HIV-1 envelope and neutralizes infection   Pages (3009-3021)
Inès Sahnoune, Andréa Cottignies-Calamarte, Annouk Dauvilliers, Kingsley Essemiah, Tahar Bouceba, Christophe Piesse, Daniela Tudor, Morgane Bomsel
An endoplasmic reticulum-targeting photodynamic AMPK agonist activates breast cancer immunotherapy through promoting immunogenic cell death and downregulation of PD-L1   Pages (3022-3035)
Ye-yang Wu, Ke-yang Zhang, Jia-qi Huang, Jun-mei Nie, Hong Cheng
Hepatitis B virus core protein promotes liver cancer progression by stabilizing CANX and suppressing IRF7 transcription   Pages (3036-3052)
Hong-juan You, Huan-yang Zhang, Yu-jie Zhong, Ru-yu Liu, Lu Yang, Rong Jiang, Yu-xin Wang, En-si Bao, Xiang-ye Liu, Chen Li, Xiu-cheng Pan, Xu-feng Huang, Kui-yang Zheng, Ren-xian Tang, Fan-yun Kong
CD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12+ microglia transformation   Pages (3053-3070)
Pan-pan Gao, Hai-feng Jiang, Yu-wen Du, Ya Shu, Yu-wei Wan, En-zhi Yin, Jia-xing Wu, Xin-xin Liang, Si-dao Wang, Ze-hua Ding, Xiao-hong Xu, Qi An, Cheng Miao, Xi-miao He, Ming-feng Li, Feng Liu, Xiao-qian Chen
Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation   Pages (3071-3086)
Zhen-chuan Wang, Chen Li, Zhao Zhang, Shan Lu, Ying-min Liu, Peng Qi, Xi Chen, Yu-bo Wang, Wen-jie Feng, Cheng-liang Pan, Qing-xuan Wang, Zhi-lin Ji, Ying Yu, Mei-hua Piao, Guang-fan Chi, Peng-fei Ge
Modeling exposure-driven adverse events of EGFR TKIs in the treatment of patients with non-small cell lung cancer   Pages (3087-3098)
Ling Yong, Yan’e Liu, Wei-zhe Jian, Lei Cai, Tian-yu Bao, Chen Liu, En-ze Gan, Tian-yu Wang, Ping-yao Luo, Bao-shan Cao, Wei Liu, Tian-yan Zhou
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor   Pages (3099-3107)
Ze-chen Wang, Yue Zeng, Jin-yuan Sun, Xue-qin Chen, Hao-chen Wu, Yang-yang Li, Yu-guang Mu, Liang-zhen Zheng, Zhao-bing Gao, Wei-feng Li
Discovery of novel GluN1/GluN3A NMDA receptor inhibitors using a deep learning-based method   Pages (3108-3115)
Shi-hang Wang, Yue Zeng, Hao Yang, Si-yuan Tian, Yong-qi Zhou, Lin Wang, Xue-qin Chen, Hai-ying Wang, Zhao-bing Gao, Fang Bai
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors   Pages (3116-3128)
Kun Li, Yue Zeng, Yi-da Xiong, Hao-chen Wu, Sui Fang, Zhi-yan Qu, Yan Zhu, Bo Du, Zhao-bing Gao, Wen-bin Hu