%0 Journal Article %T Anti-inflammatory effect of bacillus subtilis neutral protease %A Zhou Zhong-da %A Wang Ping %A Zhou Xiao-lin %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Anti-inflammatory effect of bacillus subtilis neutral protease %K %X A neutral peptidase was isolated from Bacillus subtilis (A.S. 1. 398). Intraduodenal injection of this protease 40 mg/kg showed a significant anti-inflammatory effect on acute egg albumin-induced edema of hind paws in rats and a weak fibrinolytic activity (60 Vg/ml) in vitro. The [l25I]protease by intraduodenal injection was absorbable from small intestine. Acute ip LD50 in mice was 45 (95% fiducial limits 27 and 55) mg/kg. Hence this protease has a low toxicity. strong anti-inflammatory effect. %U http://www.chinaphar.com/article/view/8530 %V 4 %N 3 %P 214-216 %@ 1745-7254