Original Articles

IL-10 and trichosanthin inhibited surface molecule expression of antigen processing cells and T-cell proliferation

Zu-sen Fan, Bao-li Ma


To study immunoinhibitory effects and preliminary mechanism of IL-10 and trichosanthin.
Surface molecule expression on antigen processing cells (APC) was stained with fluorescence and analyzed by FACScan. B7-1 mRNA expression was detected with nested RT-PCR.
IL-10 2 mg.L-1 and trichosanthin 10 mg.L-1 inhibited B7-1 molecule expression. By contrast, they had not the same effects on ICAM-1. IL-10 and trichosanthin down-regulated LFA-1 expression, but had no regulatory effect on CD40. IL-10 and trichosanthin dramatically inhibited T-cell proliferation and IL-2 production. B7-1 mRNA expression was undetectable in APC treated with IL-10 and trichosanthin.
IL-10 and trichosanthin inhibit surface molecule expression on APC. They exert multiple immunoinhibitory effects.

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