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IL-10 and trichosanthin inhibited surface molecule expression of antigen processing cells and T-cell proliferation

   
@article{APS7649,
	author = {Zu-sen Fan and Bao-li Ma},
	title = {IL-10 and trichosanthin inhibited surface molecule expression of antigen processing cells and T-cell proliferation},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study immunoinhibitory effects and preliminary mechanism of IL-10 and trichosanthin.
METHODS:
Surface molecule expression on antigen processing cells (APC) was stained with fluorescence and analyzed by FACScan. B7-1 mRNA expression was detected with nested RT-PCR.
RESULTS:
IL-10 2 mg.L-1 and trichosanthin 10 mg.L-1 inhibited B7-1 molecule expression. By contrast, they had not the same effects on ICAM-1. IL-10 and trichosanthin down-regulated LFA-1 expression, but had no regulatory effect on CD40. IL-10 and trichosanthin dramatically inhibited T-cell proliferation and IL-2 production. B7-1 mRNA expression was undetectable in APC treated with IL-10 and trichosanthin.
CONCLUSION:
IL-10 and trichosanthin inhibit surface molecule expression on APC. They exert multiple immunoinhibitory effects.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7649}
}