Original Article

Mutagenic effects of bimolane

Authors: Sen-qing CHEN, Kai-xian XUE, Jian-zhong WU, Guo-jian MA

Abstract

AIM:
To study the genotoxicity of bimolane.
METHODS:
Bimolane 5, 10, and 15 mg . kg-1 was injected i.p. in mice to investigate its effects on chromosome/chromatid aberrations of bone marrow cells. Mutagenic effects on TA97, TA98, TA100, TA102 were studied in Ames test.
RESULTS:
Bimolane 5, 10, and 15 mg . kg-1 induced of chromosome/chromatid aberrations, and the frequency of aberration cells (ACF) induced by bimolane increased markedly (P < 0.01); Bimolane without S9 showed mutagenic to TA98 and TA102 at the concentrations of 100 and 150 micrograms/plate in Ames test.
CONCLUSION:
Bimolane is a kind of genotoxic compound.
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