TY - JOUR AU - CHEN Sen-qing AU - XUE Kai-xian AU - WU Jian-zhong AU - MA Guo-jian PY - 2016 TI - Mutagenic effects of bimolane JF - Acta Pharmacologica Sinica; Vol 16, No 6 (November 1995): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - AIM: To study the genotoxicity of bimolane. METHODS: Bimolane 5, 10, and 15 mg . kg-1 was injected i.p. in mice to investigate its effects on chromosome/chromatid aberrations of bone marrow cells. Mutagenic effects on TA97, TA98, TA100, TA102 were studied in Ames test. RESULTS: Bimolane 5, 10, and 15 mg . kg-1 induced of chromosome/chromatid aberrations, and the frequency of aberration cells (ACF) induced by bimolane increased markedly (P < 0.01); Bimolane without S9 showed mutagenic to TA98 and TA102 at the concentrations of 100 and 150 micrograms/plate in Ames test. CONCLUSION: Bimolane is a kind of genotoxic compound. UR - http://www.chinaphar.com/article/view/7092