Original Article

Genetic effects of fluorocarbon emulsion on germinal cells of male mice

Authors: Bao-zhen ZHONG, Qi-ni TANG, Pei-jun XIN, Bing-sheng WANG


The A strain male mice were infused with fluorocarbon emulsion (FCE) 50, 10 ml/kg and NS 50 ml/kg. Metaphase plates of spermatogonia and spermatocytes I were examined on d 7 after infusion and histological damage of the testes was studied by light and electron microscopes.
The frequencies of aneuploid and polyploidy of spermatogonia were 2.9, 2.5, and 1.4%, respectively induced by FCE 50, 10 ml/kg and NS 50 ml/kg. While those of breaks and reciprocal translocations were 0.5, 0.1 and 0.2%, respectively. In spermatocytes I the frequency of X-Y univalent and autosomal univalent were 2% (P<0.05) and no morphological changes were found in spermatogonia developed from spermatogenic cells.
It may be concluded that no chromosomal aberrations were induced in germinal cells of male mice by FCE.

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