Effect of oxymatrine on isolated heart atria of rabbits
Abstract
Oxymatrine, isolated from Sophora alopecuroides, increased the contractility of the left heart atrium of rabbit dose-dependently and decreased the contractility and excitability, when the cumulative dose reached the toxic level (360 microM).
Oxymatrine 9 microM increased the automaticity induced by epinephrine and shortened the functional refractory period, but did not shift the intensity-duration curve. On the right atrium oxymatrine 9 microM also decreased the spontaneous rate and the positive chronotropic effect induced by CaCl2.
Keywords:
Oxymatrine 9 microM increased the automaticity induced by epinephrine and shortened the functional refractory period, but did not shift the intensity-duration curve. On the right atrium oxymatrine 9 microM also decreased the spontaneous rate and the positive chronotropic effect induced by CaCl2.