Original Article

Antagonistic effect of ascorbic acid on caffeine-induced elevation of cerebrospinal fluid Ca2+ in rabbits

Mu-qun CHEN, Suo-di ZHAI, Ping ZHENG, Zuo-hui SHAO, Xiu-rong JIA, Yu-gui LI, Li-ping DONG


Intracerebroventricular injection (icv) of caffeine 3.5 or 3.75 mg/kg into rabbits elevated the Ca2+ concentrations in cerebrospinal fluid (CSF). When pretreated with ascorbic acid (62.5 mg/kg) or sodium D-isoascorbate (30 mg/kg), the Ca2+ in CSF were decreased in a dose-dependent manner. These results indicate that the ascorbic acid or sodium D-isoascorbate antagonizes the icv caffeine-induced elevation of Ca2+ in CSF of rabbits.

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