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Antagonistic effect of ascorbic acid on caffeine-induced elevation of cerebrospinal fluid Ca2+ in rabbits

   
@article{APS4970,
	author = {Mu-qun CHEN and Suo-di ZHAI and Ping ZHENG and Zuo-hui SHAO and Xiu-rong JIA and Yu-gui LI and Li-ping DONG},
	title = {Antagonistic effect of ascorbic acid on caffeine-induced elevation of cerebrospinal fluid Ca2+ in rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Intracerebroventricular injection (icv) of caffeine 3.5 or 3.75 mg/kg into rabbits elevated the Ca2+ concentrations in cerebrospinal fluid (CSF). When pretreated with ascorbic acid (62.5 mg/kg) or sodium D-isoascorbate (30 mg/kg), the Ca2+ in CSF were decreased in a dose-dependent manner. These results indicate that the ascorbic acid or sodium D-isoascorbate antagonizes the icv caffeine-induced elevation of Ca2+ in CSF of rabbits.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4970}
}