Original Articles

CaCl2-ACh induced atrial fibrillation (flutter) in mice

Zi-yan Zhao, Yan-mim Guo


Atrial fibrillation (flutter) was induced by iv CaCl2-ACh in 73 of 80 mice (91%). Quinidine showed a significant protection. Verapamil, propranolol and diphenylhydantoin gave some protection when they were iv at the doses of about 1/2 LD50. Lidocaine had negligible effects. This procedure may be used for screening of drugs for the advantages of low cost, simple techniques and definite end points.

Article Options

Download Citation

Cited times in Scopus