Magnesium lithospermate B ameliorates renal cortical microperfusion in rats
Abstract
Aim: To investigate the effects of magnesium lithospermate B (MLB) isolated
from Salviae miltiorrhizae on renal microcirculation, and renal and systemic hemodynamics
in Sprague-Dawley rats. Methods: MLB (10, 30, and 60 mg/kg) was
injected intravenously and renal blood flow (RBF), renal cortical microperfusion
(RCM), and systemic hemodynamic function parameters including heart rate (HR),
mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), left ventricular
end-diastolic pressure (LVEDP), and maximal velocity of pressure increase
(dp/dtmax) were measured for 45 min after administration. Results: Intravenous
MLB at doses of 10, 30, and 60 mg/kg increased RCM significantly, but had no
obvious effects on RBF or systemic hemodynamics. The effect of MLB on RCM
reached its peak 15 min after injection and returned to baseline after 45 min. Up to
60 mg/kg MLB increased RCM by 62.4%±20.2% (changes from baseline, P<0.01),
whereas RBF (3.7%±9.7% vs baseline) and renal vascular resistance (-1.4%±9.1%
vs baseline) did not obviously change. Conclusion: These results indicate that
MLB ameliorates renal microcirculation in a dose-dependent manner, which may
be related to the renoprotective effects of MLB.
Keywords:
from Salviae miltiorrhizae on renal microcirculation, and renal and systemic hemodynamics
in Sprague-Dawley rats. Methods: MLB (10, 30, and 60 mg/kg) was
injected intravenously and renal blood flow (RBF), renal cortical microperfusion
(RCM), and systemic hemodynamic function parameters including heart rate (HR),
mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), left ventricular
end-diastolic pressure (LVEDP), and maximal velocity of pressure increase
(dp/dtmax) were measured for 45 min after administration. Results: Intravenous
MLB at doses of 10, 30, and 60 mg/kg increased RCM significantly, but had no
obvious effects on RBF or systemic hemodynamics. The effect of MLB on RCM
reached its peak 15 min after injection and returned to baseline after 45 min. Up to
60 mg/kg MLB increased RCM by 62.4%±20.2% (changes from baseline, P<0.01),
whereas RBF (3.7%±9.7% vs baseline) and renal vascular resistance (-1.4%±9.1%
vs baseline) did not obviously change. Conclusion: These results indicate that
MLB ameliorates renal microcirculation in a dose-dependent manner, which may
be related to the renoprotective effects of MLB.