Vol 47, No 7 (July 2026): Acta Pharmacologica Sinica

Review Article

Intergenerational effects of the microbiota on neurodevelopment: mechanisms and therapeutic perspectives   Pages (1695-1717)
Ruo-xi Wang, Ali Afzal, Xiao-yuan Jing, Yu Zhou, Jin-xing Feng, Zu-xin Chen, De-zhi Cao, Xin-an Liu
The serotonin-gated 5-HT3 receptor: a tale of functions and structures of a prototypical pentameric ligand-gated ion channel   Pages (1718-1732)
Zhong-jie Ye, Chen-yang Wu, Hang Zhang, Hua-wei Zhang, Horst Vogel
Technology-enabled insights into SLC transporters in MAFLD: redefining the multi-hit pathogenesis and therapeutic landscape   Pages (1733-1748)
Joseph Tawai, Jing Xiong

Article

Sonic Hedgehog-Gli1 signaling promotes microglial activation via the IKKβ/NF-κB pathway   Pages (1749-1764)
Zhi-rou Xu, Kan Wu, Rui-ying Guo, Peng Wang, Jia-wei Ou-Yang, Zhong-qiang Cao, Hui-cui Yang, Jong-Heon Kim, Xiao-hu Zhang, Kyoungho Suk, Xue-chu Zhen, Yuan Wang, Xiang-dong Du, Long-tai Zheng
Hippocampal REDD1 inhibition is critical for alleviating depressive-like behaviors   Pages (1765-1776)
Chen Xu, Meng-xing Liao, Shi-ze Zhang, Lai-xin-yue Shu, Peng Xu, Yu-ang Chen, Meng-qin Wang, Tian Cheng, Xu-le Yang, Yuan Xie, Guang-ji Wang, Ji-ye Aa
IL-17A in the hippocampus regulates despair-like behaviors via inhibitory synaptic transmission   Pages (1777-1791)
Yue Wang, He-ming Yu, Yong He, Jun-chao Cai, Yu Tian, Xiang-yu Chen, Qing-yuan Wu, Ti-fei Yuan, An-mu Xie, Yi Guo, Ke Cheng, Peng Xie
Selective inhibition of monoamine oxidase B represents a therapeutic strategy for diabetic peripheral neuropathy   Pages (1792-1808)
Ni-xue Song, Yan-chun Wang, Tong Zhao, Zhi-shuo Zhang, Jia-cheng Liu, Zi-yun Chen, Yu-jie Huang, Jia-ying Wang, Xu Shen
TMEM175 rescues post-infarct cardiac dysfunction via mTORC1-lysosomal axis modulation   Pages (1809-1824)
Chen Chen, Han Lou, An-ge Hu, Qiang Huang, Ling-yi Kong, Zhou-xiu Chen, Heng-hui Xu, Yong-chao Chen, Heng Liu, Shu-qin Duan, Yuan Lin, Li-min Zhao, Ling Liu, Muneer Ahmed Khoso, Xin Liu, Yong Zhang
Cannabidiol inhibits both human KV7.1 and KV7.1/KCNE1 channels through distinct sites   Pages (1825-1839) Open
AS Kusay, M. Pökl, I. Hiniesto-Iñigo, A. Sridhar, L. Delemotte, SI Liin
A potential therapeutic effect of 84-B10 in MASLD through promotion of FASN degradation   Pages (1840-1855)
Yi-peng Bai, Yin Yin, Su-man Wang, Jiang-ming Chen, Ze-hua Zhang, Zi-qi Zhu, Guang-xin Shao, Yong Zhu, Yi-yang Jiang, Bei-cheng Sun, Deng-qiu Xu
Chlorogenic acid promotes liver regeneration after partial hepatectomy through activating Nrf2 via directly targeting Keap1   Pages (1856-1867)
Hao-yu Xue, Xin-nan Gu, Zhuang Huang, Ze Zhang, Kun-yu Zhang, Zhen-lin Huang, Bin Lu, Jian-gao Fan, Meng-juan Wei, Li-li Ji
MIF tautomerase inhibitor 4-IPP alleviates HFD-induced obesity by restoring CD137-mediated browning of white adipocytes in mice   Pages (1868-1883)
Chuan-jun Chen, Ding-wen Guo, Qing-yun Yuan, You-qiong Zhuo, Shi-fen Yang, Hao-min Xu, You-rong Wang, Xiao-hui Guan, Ke-yu Deng, Hong-bo Xin
IG20/MADD gene functional isoform KIAA0358 can promote insulin secretion in glucose and repaglinide-induced pancreatic β-cells   Pages (1884-1899)
Yi Sui, Zhao-lei Weng, Li-xia Qian, Wan-jin Hong ✉, Bellur S. Prabhakar, Liang-cheng Li
AI-driven pipeline discovers ombuin as a novel M1 macrophage polarization inhibitor for sepsis treatment   Pages (1900-1916)
Shu-chen Gong, Lan Jiang, Qi-xiu Li, Chen Yang, Le Yu, Shu-ying Lv, Guang Yang, Zhao-xu Yang, Han Huang, Yu-ming Hu, Xiao-yu Chen, Hao-yu Zhang, Bo Yang, Qiao-jun He, Qin-jie Weng, Jin-cheng Wang
Chloroethylnitrosourea analogue HJ03 overcomes temozolomide resistance of glioblastoma in mice through induction of ferroptosis and apoptosis   Pages (1917-1930)
Heng Yang, Yi Cao, Wei Zhao, Ying-fan Wen, Yan Wu, Ting Wang, Li-zhi Zhu, Yong-dong Zou, Bao-min Xi, Duo Zheng
GSDME-mediated pyroptosis modulates the immunosuppressive microenvironment in lung adenocarcinoma   Pages (1931-1943)
Guang-sheng Zhu, Xuan-guang Li, Pei-jun Cao, Ya-nan Wang, Ying-jie Wang, Zi-he Zhang, Bo-shi Li, Pei-jie Chen, Yong-wen Li, Chen Chen, Hong-bing Zhang, Hong-yu Liu, Jun Chen
USP22 deubiquitinates and stabilizes ERK1/2 to promote colorectal cancer progression   Pages (1944-1954)
Guang-chao Ma, Hai-tao Yang, Gang Xu, Yu-yang Wang, Shao-hua Zhang, Ying Huang, Guo-gang Deng, Ling-mei Kong, Yan Li
Targeted tumor starvation strategy augments radiosensitivity and enhances radioactive iodine-mediated tumor immunotherapy   Pages (1955-1964)
Ying Zhang, Zhi-peng Liu, Zi-yang Zhang, Jin Tian, Ren-li Luo, Ming-mei Dong, Chuan-zheng Zhou, Jung-Joon Min, Zhen Cheng, Yeongjin Hong
Design and evaluation of peroxiredoxin 1 agonist based on scaffold hopping of salvianolic acids and combinatorial click chemistry   Pages (1965-1979)
Yu-yuan Zhu, Shuang Chen, Shu-ning Zhang, Ying-shuang Zhu, Jia-yin Liang, Zhen-yu Wang, Xiao-min Wang, Jian-jun Liu, Peng-fei Liu, Zhi-hai Li, Wei-lie Xiao, Heng Xu, Cheng Luo, Huan Xiong, Hao Zhang
Structural and dynamic insights into ligand recognition and activation of somatostatin receptor 3   Pages (1980-1989)
Xue Chen, Sen Guo, Ying-ge Li, Ao-kun Liu, Jian Kuang, Pan Shi, Lu Yu, Fan Yang, Chang-lin Tian

Correction

Correction: Aspirin alleviates cardiac fibrosis in mice by inhibiting autophagy   Pages (1990-1991)
Ping-ping Liu, Hong-hong Liu, Shu-hong Sun, Xing-xing Shi, Wan-cheng Yang, Guo-hai Su, Jing Zhao
Correction: IG20/MADD gene functional isoform KIAA0358 can promote insulin secretion in glucose and repaglinide-induced pancreatic β-cells   Pages (1992-1994)
Yi Sui, Zhao-lei Weng, Li-xia Qian, Wan-jin Hong, Bellur S. Prabhakar, Liang-cheng Li