Cannabis, cannabinoid receptors, and endocannabinoid system: yesterday, today, and tomorrow

Authors: Jie Wu
DOI: 10.1038/s41401-019-0210-3
Received: 26 December 2018
Accepted: 1 January 2019
Advance online: 22 January 2019


Cannabis sativa, is also popularly known as marijuana, has been cultivated and used for recreational and medicinal purposes for many centuries. The main psychoactive content in cannabis is Δ9-tetrahydrocannabinol (THC). In addition to plant cannabis sativa, there are two classes of cannabinoids—the synthetic cannabi-noids (e.g., WIN55212–2) and the endogenous cannabinoids (eCB), anandamide (ANA) and 2-arachidonoylglycerol (2-AG).

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