Review Article

Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitors

Authors: Wen-bin Fu1, Wei Eric Wang1, Chun-yu Zeng1
1 Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Correspondence to: Wei Eric Wang: weiericwang@163.com,
DOI: 10.1038/s41401-018-0060-4
Received: 9 January 2018
Accepted: 31 May 2018
Advance online: 12 July 2018

Abstract

Myocardial infarction (MI) is one of the most serious health threats, resulting in huge physical and economic burdens worldwide. Wnt signaling pathways play an important role in developmental processes such as tissue patterning, cell differentiation and cell division. Appropriate regulation of the activities of Wnt signaling pathways is also important for heart development and healing in post-MI heart. Moreover, Wnt pathway inhibitors have been identified as novel antitumor drugs and applied in ongoing clinical trials. This research progress has generated increasing interests for investigating the effects of Wnt pathway inhibitors on MI healing. In this short review, we summarize the roles of Wnt signaling pathways in post-MI heart and the therapeutic effects of Wnt pathway inhibitors on MI, and discuss the underlying mechanisms of Wnt pathway inhibitors in cardiac repairing.
Keywords: Wnt pathway inhibitors; myocardial infarction; cardiac repairing; therapeutic effect

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