Therapeutic effects of a taurine-magnesium coordination compound on experimental models of type 2 short QT syndrome

Meng-yao AN1, Kai SUN1, Yan LI1, Ying-ying PAN1, Yong-qiang YIN1, Yi KANG1, Tao SUN2, Hong WU1, Wei-zhen GAO1, Jian-shi LOU1
1 Department of Pharmacology, College of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
2 State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China
Correspondence to: Jian-shi LOU:,
DOI: 10.1038/aps.2017.86
Received: 25 March 2017
Accepted: 19 May 2017
Advance online: 26 October 2017


Short QT syndrome (SQTS) is a genetic arrhythmogenic disease that can cause malignant arrhythmia and sudden cardiac death. The current therapies for SQTS have application restrictions. We previously found that Mg· (NH2CH2CH2SO3)2· H2O, a taurine-magnesium coordination compound (TMCC) exerted anti-arrhythmic effects with low toxicity. In this study we established 3 different models to assess the potential anti-arrhythmic effects of TMCC on type 2 short QT syndrome (SQT2). In Langendorff guinea pig-perfused hearts, perfusion of pinacidil (20 μmol/L) significantly shortened the QT interval and QTpeak and increased rTp-Te (P<0.05 vs control). Subsequently, perfusion of TMCC (1–4 mmol/L) dose-dependently increased the QT interval and QTpeak (P<0.01 vs pinacidil). TMCC perfusion also reversed the rTp-Te value to the normal range. In guinea pig ventricular myocytes, perfusion of trapidil (1 mmol/L) significantly shortened the action potential duration at 50% (APD50) and 90% repolarization (APD90), which was significantly reversed by TMCC (0.01–1 mmol/L, P<0.05 vs trapidil). In HEK293 cells that stably expressed the outward delayed rectifier potassium channels (IKs), perfusion of TMCC (0.01–1 mmol/L) dose-dependently inhibited the IKs current with an IC50 value of 201.1 μmol/L. The present study provides evidence that TMCC can extend the repolarization period and inhibit the repolarizing current, IKs, thereby representing a therapeutic candidate for ventricular arrhythmia in SQT2.
Keywords: short QT syndrome; taurine-magnesium coordination compound; pinacidil; trapidil; Langendorff guinea pig-perfused hearts; ventricular myocytes; IKs; refractory period

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