Original Article

Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides

Authors: Shan Gong, Hui-Qin Zhang, Wei-Ping Yin, Qi-Zhang Yin, Yi Zhang, Zhen-Lun Gu, Zhong-Ming Qian, Pak-L Tang

Abstract

AIM: To study the role of interleukin-2 (IL-2) and mediobasal hypothalamus (MBH) in analgesia produced by Coriolus versicolor polysaccharide peptide (PSP). METHODS: The IL-2 antiserum was injected i.c.v. or i.p. and the MBH was destroyed electrolytically.
RESULTS: PSP i.g. 1 g.kg-1.d-1 for 6 d increased the pain threshold in tail stimulation-vocalization test in rats. This PSP-produced analgesia was blocked by i.c.v., but not i.p., IL-2 antiserum and disappeared after electrolytic lesion of MBH. CONCLUSION: The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH.
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