TY - JOUR AU - Gong Shan AU - Zhang Hui-Qin AU - Yin Wei-Ping AU - Yin Qi-Zhang AU - Zhang Yi AU - Gu Zhen-Lun AU - Qian Zhong-Ming AU - Tang Pak-L PY - 2016 TI - Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides JF - Acta Pharmacologica Sinica; Vol 19, No 1 (January 1998): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - AIM: To study the role of interleukin-2 (IL-2) and mediobasal hypothalamus (MBH) in analgesia produced by Coriolus versicolor polysaccharide peptide (PSP). METHODS: The IL-2 antiserum was injected i.c.v. or i.p. and the MBH was destroyed electrolytically. RESULTS: PSP i.g. 1 g.kg-1.d-1 for 6 d increased the pain threshold in tail stimulation-vocalization test in rats. This PSP-produced analgesia was blocked by i.c.v., but not i.p., IL-2 antiserum and disappeared after electrolytic lesion of MBH. CONCLUSION: The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH. UR - http://www.chinaphar.com/article/view/8858