Effect of phencyclidine on contraction of porcine coronary vessel strips.

Classic muscular contraction experiment was used to study the effect of phencyclidine (Phe) on spiral strips of porcine coronary vessels. It showed that Phe and its analogs: 1-[1-(2-thienyl)cyclohexyl] piperidine (TCP), (+)-5-methyl-10, 11-dihydro-5H-dibenzo [a,d] cyclohepten-5, 10-imine maleatel (dizocilpine maleate) and sigma receptor ligand N-allyl-N-normetazocine (SKF10047) all exhibited a concentration-dependent contraction of porcine coronary vessel strips. Phe had no effect on the electrically stimulated contraction of the spiral strips. Dextromethorphan (Dex), a Phe receptor antagonist, and haloperidol (Hal), a sigma receptor antagonist, partially antagonized and suppressed the actions of Phe in a non-competitive manner. These results suggested that Phe, TCP, dizocilpine maleate, and (+), (-)-SKF10047 cause contraction through Phe and sigma opioid receptors.