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Effect of phencyclidine on contraction of porcine coronary vessel strips.

   
@article{APS8746,
	author = {Gang-Gang Shi and Shao-Feng Xu},
	title = {Effect of phencyclidine on contraction of porcine coronary vessel strips.},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Classic muscular contraction experiment was used to study the effect of phencyclidine (Phe) on spiral strips of porcine coronary vessels. It showed that Phe and its analogs: 1-[1-(2-thienyl)cyclohexyl] piperidine (TCP), (+)-5-methyl-10, 11-dihydro-5H-dibenzo [a,d] cyclohepten-5, 10-imine maleatel (dizocilpine maleate) and sigma receptor ligand N-allyl-N-normetazocine (SKF10047) all exhibited a concentration-dependent contraction of porcine coronary vessel strips. Phe had no effect on the electrically stimulated contraction of the spiral strips. Dextromethorphan (Dex), a Phe receptor antagonist, and haloperidol (Hal), a sigma receptor antagonist, partially antagonized and suppressed the actions of Phe in a non-competitive manner. These results suggested that Phe, TCP, dizocilpine maleate, and (+), (-)-SKF10047 cause contraction through Phe and sigma opioid receptors.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8746}
}