Relaxation effect of bovine parathyroid hormone l-34 on rabbit aorta
Abstract
Bovine parathyroid hormone 1-34 (bPTHl-34) was studied in rabbit isolated aortic strips. It was found that bPTH1-34 lowered the basal tension of the aortic strips (IC50 48 vmol/L). Like nifedipine and verapamil. bPTHl-34 inhibited the contraction induced by BAY k 8644 (1.4 vmol/L) with an IC50 value of 0.95 vmol/L. In contrast, its inhibition of contraction induced by norepinephrine was weak. It is suggested that bPTH1-34 reduces the tension in vascular smooth muscle by acting mainly on potential sensitive calcium channels to decrease calcium transmembrane influx.
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