Original Article

Isolation and identification of the metabolite of artemisinine in human

Da-yuan Zhu, Bao-shan Huang, Zhong-liang Chen, Meng-Iong Yin, Yi-ming Yang, Man-Ji Dai, Bao-de Wang, Zhi-heng Huang


Artemisinine, a new potent anti-malarial component isolated from Artemisia annua L., was given orally to malarial patients. From their urine another metabolite was isolated and identified as 9,10-dihydroxyhydro-artemisinine by spectroscopic methods.

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