Original Article

Convulsant effects of kainic acid and dihydrofolate are antagonized by sodiuim valproate

G B De Sarro, M Cala, D Rotiroti, R Anfosso, G Nistico, E Marmo


Microinjection of dihydrofolic acid in rat caudate nucleus 10 min after kainic acid significantly enhanced the epileptic motor and ECoG discharges of the single compounds. Sodium valproate antagonized the motor and electrocortical epileptogenic disorders induced by previous intracaudate injections of kainic and dlhydrofolic acids.

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