Preparation and dissolution property of ipriflavone solid dispersion.
Abstract
AIM:
To prepare and identify ipriflavone (IP) solid dispersion, and determine its dissolution property.
METHODS:
The solvent method was used for preparation and differential scanning calorimetry (DSC), X-ray diffraction and infrared spectrophotometry for identification of IP solid dispersion. The dissolution of the dispersion was determined with paddle method.
RESULTS:
The dissolution of IP solid dispersion consisting of IP and povidone-k30 (PVP) (1:8) in artificial gastric juice is 6.15 times as high as that of IP alone. The DSC curves, X-ray diffraction patterns and infrared spectrophotometries of IP have been changed obviously by the dispersion.
CONCLUSION:
The dissolution of IP is increased by solid dispersion method.
Keywords:
To prepare and identify ipriflavone (IP) solid dispersion, and determine its dissolution property.
METHODS:
The solvent method was used for preparation and differential scanning calorimetry (DSC), X-ray diffraction and infrared spectrophotometry for identification of IP solid dispersion. The dissolution of the dispersion was determined with paddle method.
RESULTS:
The dissolution of IP solid dispersion consisting of IP and povidone-k30 (PVP) (1:8) in artificial gastric juice is 6.15 times as high as that of IP alone. The DSC curves, X-ray diffraction patterns and infrared spectrophotometries of IP have been changed obviously by the dispersion.
CONCLUSION:
The dissolution of IP is increased by solid dispersion method.