@article{APS8296,
author = {Ya-ping Li and Xian-ying Zhang and Jian-jun Zhou and Yuan-ying Pei},
title = {Preparation and dissolution property of ipriflavone solid dispersion.},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {10},
year = {2016},
keywords = {},
abstract = {AIM:
To prepare and identify ipriflavone (IP) solid dispersion, and determine its dissolution property.
METHODS:
The solvent method was used for preparation and differential scanning calorimetry (DSC), X-ray diffraction and infrared spectrophotometry for identification of IP solid dispersion. The dissolution of the dispersion was determined with paddle method.
RESULTS:
The dissolution of IP solid dispersion consisting of IP and povidone-k30 (PVP) (1:8) in artificial gastric juice is 6.15 times as high as that of IP alone. The DSC curves, X-ray diffraction patterns and infrared spectrophotometries of IP have been changed obviously by the dispersion.
CONCLUSION:
The dissolution of IP is increased by solid dispersion method.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8296}
}