Inhibitory effects of succinic acid on chemical kindling and amygdala electrical kindling in rats.

AIM: To investigate the effects and mechanism of succinic acid on
pentylenetetrazol (PTZ) chemical kindling and amygdala electrical kindling in
rats.
METHODS: PTZ chemical kindling and amygdala electrical kindling models were
established in rats. The effects of succinic acid on the behavior and
afterdischarge of kindled rats were observed. The mice were pretreated with
succinic acid, 30 min later, picrotoxin, a GABAA receptor antagonist was given by
ip, then the effects of succinic acid on mice were observed.
RESULTS: Succinic acid (100-400 mg/kg, ip) dose-dependently inhibited PTZ
chemical and amygdala kindled seizure (P<0.05, P<0.01), elevated the
afterdischarge threshold, and reduced the Racine's stage of amygdala kindling
rats (P<0.05, P<0.01); succinic acid (200-400 mg/kg, ip) inhibited
picrotoxin-convulsion in mice (P<0.05, P<0.01).
CONCLUSION: Succinic acid inhibits PTZ chemical and amygdala electrical kindling
in rats, and the inhibition mechanism may be related to the enhancement of
GABAergic system action in the brain, especially through GABAA receptors.