@article{APS7761,
author = {Wang YUE and Yan-Xia LIU and Dong-Lian ZANG and Ming ZHOU and Fang ZHANG and Lei WANG},
title = {Inhibitory effects of succinic acid on chemical kindling and amygdala electrical kindling in rats.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {9},
year = {2016},
keywords = {},
abstract = {AIM: To investigate the effects and mechanism of succinic acid on
pentylenetetrazol (PTZ) chemical kindling and amygdala electrical kindling in
rats.
METHODS: PTZ chemical kindling and amygdala electrical kindling models were
established in rats. The effects of succinic acid on the behavior and
afterdischarge of kindled rats were observed. The mice were pretreated with
succinic acid, 30 min later, picrotoxin, a GABAA receptor antagonist was given by
ip, then the effects of succinic acid on mice were observed.
RESULTS: Succinic acid (100-400 mg/kg, ip) dose-dependently inhibited PTZ
chemical and amygdala kindled seizure (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7761}
}