Original Articles

Inhibition by baclofen of NMDA-activated current in rat dorsal root ganglion neurons

Jun-qiang Si, Zhi-wang Li


To explore the modulatory effect of baclofen on NMDA-activated current in rat dorsal root ganglion (DRG) neurons.
Whole-cell patch-clamp technique was used to record NMDA-activated current in isolated DRG neurons. Drugs were applied by rapid solution exchange.
Preapplication of baclofen 1-100 mumol.L-1 induced a concentration-dependent inhibition of the inward NMDA-activated current markedly. NMDA (100 mumol.L-1)-activated current was inhibited by 52% +/- 14% (n = 11, P < 0.01) by preapplication of baclofen 100 mumol.L-1. The inhibitory effect of baclofen was reversible, and was removed by saclofen 100 mumol.L-1, which was a selective antagonist of GABAB receptor.
Preapplication of baclofen exerts an inhibitory effect on NMDA-activated current in the primary sensory neurons.

Article Options

Download Citation

Cited times in Scopus