Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium
Abstract
Aim: To investigate the anti-implantation mechanism of mifepriston.
Methods: In situ hybridization and immunohistochemistry were applied to determine mRNA and protein.
Results: After mifepriston injection, the number of implantation sites were obviously reduced, mifepriston could inhibit the embryo implantation in mouse. The expression of apoptosis related genes, Fas and FasL, in mouse endometrium was also decreased after mifepriston treatment.
Conclusion: The expression of apoptosis related genes Fas and FasL is regulated by mifepriston and the inhibitory effect of mifepriston on the embryo implantation may be mediated by action on the Fas/FasL system.
Keywords:
Methods: In situ hybridization and immunohistochemistry were applied to determine mRNA and protein.
Results: After mifepriston injection, the number of implantation sites were obviously reduced, mifepriston could inhibit the embryo implantation in mouse. The expression of apoptosis related genes, Fas and FasL, in mouse endometrium was also decreased after mifepriston treatment.
Conclusion: The expression of apoptosis related genes Fas and FasL is regulated by mifepriston and the inhibitory effect of mifepriston on the embryo implantation may be mediated by action on the Fas/FasL system.