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Antcin A contributs to anti-inflammatory effect of Niuchangchih (Antrodia camphorata)

Authors: Zhen-ming Lu, Zheng-hong Xu
DOI: 10.1038/aps.2011.104


Inflammation is the responses of body to harmful stimuli in many pathological conditions. Prevention and treatment of inflammation are the main indication of a variety of natural products. Recently, Niuchangchih (Antrodia camphorata), a medicinal mushroom in Taiwan, has received considerable attention from the public due to its potent bioactivities, such as anti-inflammation, anti-cancer, immuno-modulatory and anti-hepatitis activities[1]. Till now, researchers have identified a total of 26 compounds from Niuchangchih, including 11 succinic/maleic acid derivatives, 8 triterpenoids, 1 benzenoids, 1 benzoquinone derivative, 5 miscellaneous compounds and polysaccharides, that possess antiinflammatory effect[2, 3]. However, the mechanisms underlying their antiinflammatory actions remain elusive.

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