Effect of brucine on mouse nonspecific immune responses
Abstract
AIM: To evaluate the effect of brucine (Bru) i.p. at analgesic doses on the
nonspecific immune responses in normal and cyclophosphamide (Cyc)-treated mice.
METHODS: The clearance of charcoal particles, the immune organ weights, the white
blood cell counts in peripheral blood, the phagocytosis to neutral red (NR) of
PMO and its IL-1 production in vitro were tested.
RESULTS: In normal mice, Bru slightly enhanced the clearance of charcoal
particles, the phagocytosis of PMO, IL-1 production, the immune organ weights and
the WBC counts (P > 0.05), whereas in Cyc-induced subnormal immunity model mice,
Bru greatly enhanced these nonspecific immune responses (P < 0.05 or P < 0.01).
The effects of Bru were most marked i.p. at 10 mg.kg-1 in vivo or 0.1-10 mg.L-1
in vitro.
CONCLUSION: Bru i.p. at an analgesic dosage has dose- and function-dependent
immunoregulatory effects.
Keywords:
nonspecific immune responses in normal and cyclophosphamide (Cyc)-treated mice.
METHODS: The clearance of charcoal particles, the immune organ weights, the white
blood cell counts in peripheral blood, the phagocytosis to neutral red (NR) of
PMO and its IL-1 production in vitro were tested.
RESULTS: In normal mice, Bru slightly enhanced the clearance of charcoal
particles, the phagocytosis of PMO, IL-1 production, the immune organ weights and
the WBC counts (P > 0.05), whereas in Cyc-induced subnormal immunity model mice,
Bru greatly enhanced these nonspecific immune responses (P < 0.05 or P < 0.01).
The effects of Bru were most marked i.p. at 10 mg.kg-1 in vivo or 0.1-10 mg.L-1
in vitro.
CONCLUSION: Bru i.p. at an analgesic dosage has dose- and function-dependent
immunoregulatory effects.