Original Article

Puerarin inhibits tetrodotoxin-resistant sodium current in rat dorsal root ganglion neurons.

Hong-Long Ji, Tian-You Wang



To test if puerarin (Pue) affects slow sodium current in dorsal root ganglion (DRG) neurons.


Tetrodotoxin resistant (TTXr) sodium current was recorded with whole cell patch clamp technique on DRG neurons of young adult rats.


Pue 0.01-2 mmol.L-1 inhibited TTXr sodium current by 9.5%-83.2%. The inhibition was concentration-dependent and partially reversible, but was not use-dependent nor voltage-dependent. Pue did not affect the inactivation but changed the potential for half maximal conductance from -26 mV to -16 mV, suggesting the activation process was inhibited.


Pue moderately inhibits TTXr sodium current of rat DRG neurons.

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