@article{APS6349,
author = {Hong-Long Ji and Tian-You Wang},
title = {Puerarin inhibits tetrodotoxin-resistant sodium current in rat dorsal root ganglion neurons.},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {2},
year = {2016},
keywords = {},
abstract = {\"AIM:
To test if puerarin (Pue) affects slow sodium current in dorsal root ganglion (DRG) neurons.
METHODS:
Tetrodotoxin resistant (TTXr) sodium current was recorded with whole cell patch clamp technique on DRG neurons of young adult rats.
RESULTS:
Pue 0.01-2 mmol.L-1 inhibited TTXr sodium current by 9.5%-83.2%. The inhibition was concentration-dependent and partially reversible, but was not use-dependent nor voltage-dependent. Pue did not affect the inactivation but changed the potential for half maximal conductance from -26 mV to -16 mV, suggesting the activation process was inhibited.
CONCLUSION:
Pue moderately inhibits TTXr sodium current of rat DRG neurons.
\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6349}
}