Triggered activities induced by cesium chloride and terminated by drugs in cat heart in vivo
Abstract
Monophasic action potential (MAP) of the left ventricular epicardium in vivo in 58 cats were recorded by using a contact electrode. The results showed that early after depolarization, delayed after depolarization, oscillatory afterpotential, and some kinds of triggered arrhythmias were induced by CsCl (iv 0.5 mmol.kg-1), that these afterdepolarizations and triggered arrhythmias were prevented by sodium valproate, and that ventricular tachycardias induced by CsCl was terminated by lidocaine, moricizine, and sodium valproate.
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