Effects of phencyclidine analogs and phencyclidine/sigma ligands on vasoconstrictor response of rat mesenteric arteries induced by electrical field stimulation

Using the model of perfused mesenteric arteries of rat, we studied the effect of phencyclidine (PCP), N-[1-(2-thienyl)cyclohexyl] piperidine (TCP), N,N-dimethylphenylcyclohexylamine (PCDA), N-(iso-propyl)-1-phenylcyclohexylamine (PCIPA), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801), (+),(-)-N-allylnormetazocine (SKF 10 047), dextrorphan, and levorphanol on vasoconstrictor response induced by electrical field stimulation. PCP, TCP, PCDA, PCIPA, MK-801, levorphanol, and (-)-SKF 10 047 were found to increase the vasoconstrictor response in dose-dependent manner. The dose-effect curves of these compounds were similar to the curve of PCP. Although dextrorphan, an antagonist for PCP receptors, did not affect the vasoconstrictor response, it could non-competitively antagonize PCP's action. These studies suggest that some PCP analogs and PCP/sigma ligands may enhance the vasoconstrictor response induced by electrical field stimulation via action on PCP receptors.