Original Article

Antifertility actions of gossypol derivatives and analogues

Wen-hua WANG, Zong-han YU, Ming CAI, Xiao-mei XU, Guo-pei WU


This paper reports the results of 32 gossypol derivatives and analogues. Among 12 compounds screened by oral administration to male rats, only dipotassium gossypolate (NC030) exhibited an antifertility activity similar to gossypol. Among 24 compounds screened by injecting into pouches of cauda epididymides of rats, 10 exhibited spermicidal activities.

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