Original Article

Anti-arrhythmic effects of matrine

Bao-heng ZHANG, Nian-sheng WANG, Xue-jun LI, Xiang-jun KONG, Yu-li CAI


Matrine (MT) is an alkaloid isolated from Sophra alopecuroids L. The LD50 of MT iv to mice was 72.1 mg/kg (95% CL 68.2-76.5 mg/kg). MT had significant effects on different experimental models of arrhythmias induced by aconitine, barium chloride or coronary ligation. The ECG of anesthetized rats was significantly changed after iv of MT. The HR was retarded and the PR and QTc intervals were prolonged.

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