Evaluation of phototoxic effects of chlorquine and eleven other antimalarials in mice
Abstract
The phototoxicity of anti-malarials was studied in mice that were irradiated for 24 h with black light in 22+/-1 degrees. No phototoxicity was observed within 7 d in mice after: 1) ig 1/4 LD50 with 12 antimalarials (chloroquine phosphate, piperaquine phosphate, hydroxypiperaquine phosphate, quinine sulfate, mefloquine hydrochloride, cycloquine hydrochloride, mequinacrine hydrochloride, artesunate (sodium dihydroartemisinin succinate), pyronaridine phosphate, cyclochloroquanide hydrochloride, pyrimethamine, primaquine phosphate); 2) iv 1/2-1/4 LD50 with the former 4 drugs; 3) ip 1/8 LD50 qd*7 d with the former 5 drugs.
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