Original Articles

Effects of matrine on myocardial contraction and arrhythmia in isolated heart atria

Authors: Hong-Bo Xin, Shi-Fang Liu

Abstract

Matrine (Ma) was extracted from the seeds and leaves of Sophora alopecuroides L. Ma showed negative chronotropic and positive inotropic actions in the isolated guinea pig right atrium and reduced the maximal driving frequency (MDF) in the isolated guinea pig left atrium in a concentration-dependent manner. Its negative MDF action were also correlated with its negative chronotropic and positive inotropic actions. Ma inhibited the automaticity in the isolated rat left atrium induced by aconitine or prolonged the latent period of the automaticity and reduced its initial rate. The threshold concentration inducing arrhythmia by ouabain in the isolated guinea pig right atrium or automaticity by adrenaline in the isolated guinea pig left atrium as well as the positive inotropic action of ouabain were increased by Ma. These results suggest that the anti-arrhythmic action of Ma be related to its direct effects on heart.
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