Effects of ascorbic acid on hemodynamics in anesthetized open-chest dogs and rabbits
Abstract
Ascorbic acid l00 or 300 mg/kg iv increased systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP), dp/dtmax and VCE at dp/dtmax while ascorbic acid 300 mg/kg iv increased cardiac index (CI) but decreased time constant of isovolumic diastolic pressure decay (T value) significantly in open-chest dogs. Besides, ascorbic acid 300 mg/kg iv decreased TPR in open-chest rabbits in experimental acute heart failure. All the results suggest that iv ascorbic acid increases cardiac contractility and improves cardiac functions, especially during heart failure.
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