Original Article

A combined perfusion-compartmental pharmacokinetic model used to estimate presystemic metabolism of erythromycin in dogs

Authors: Sheng-kai HUANG, Xi WU, Sheng HANG, Rong YANG, Hai-tong ZHUO

Abstract

The equations derived from a combined perfusion-compartmental pharmacokinetic model, a physiological model pattern, were used to estimate presystemic metabolism of erythromycin in 4 dogs as an available measurement through portal and femoral vein after iv erythromycin lactobinate 10 and 40 mg/kg, respectively. Extensive gut lumen degradation was noted whereas the gut wall metabolism was negligible in dogs. The gut wall and liver extraction ratio were 0.016 and 0.171, respectively. The fractions of dose cleared by the gut lumen, gut wall and liver were 0.906, 0.001, and 0.016, respectively.
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