Original Article

Pharmacodynamics of 5-(1,3,3-trimethylindolinyl) N, N-dimethyl carbamate in mice

Authors: Jie-fu JIN, Ru-heng HUANG


5-(1,3,3-Trimethylindolinyl) N, N-dimethyl carbamate (TMDMC) is a strong cholinesterase inhibitor. The concentration (C) in blood of mice was measured after ip TMDMC 1.5 mg/kg and the % inhibition of blood and brain cholinesterases were calculated by following equations:
Ln[Eblood/(100-Eblood)]=3.58+/-0.9941 ln Cblood
Ln[Ebrain/(100-Ebrain)]=1.91+/-ln Cblood
The inhibition of brain cholinesterase was estimated by the following equation from the degree of blood cholinesterase inhibited.
ln Ebrain=3.67 Eblood+3.69
Measuring the extent of miosis (M) of mice following in TMDMC 1.0, 0.5, 0.25 mg/kg the blood concentration (C) was calculated by the equation:
Ln (M/(100-M))=3.65+1.006 ln C

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