Nephrotoxicity of cisplatin
Abstract
A single ip injection 5 mg/kg and 1 mg/(kg∙d)×5 d of cisplatin to rats caused the increases in blood urea nitrogen and serum creatinine. Ultrastructural observation revealed that the degenerative changes in the epithelial cells of tubules were predominantly in the proximal convoluted tubules. These data indicated that the nephrotoxicity after a single ip injection of 5 mg/kg was severer than that after 5 daily injections of 1 mg/kg.
Cisplatin killed the primarily cultured kidney cells of rat and human fetus, and also inhibited the [3H]TdR incorporation into DNA in kidney cells of rats.
These observations suggest that the nephrotoxicity of cosplatin might be related to its inhibitory effects on the synthesis of DNA in kidney cells.
Keywords:
Cisplatin killed the primarily cultured kidney cells of rat and human fetus, and also inhibited the [3H]TdR incorporation into DNA in kidney cells of rats.
These observations suggest that the nephrotoxicity of cosplatin might be related to its inhibitory effects on the synthesis of DNA in kidney cells.