Distribution of [nitrile-14C ]rorifone in mice by whole body autoradiography

10-methyl-sulphonyl-decyl[14C]-nitrile([nitrile-14C]rorifone) was given to♂ mice by intragastric gavage about 152 kBg and the mice were frozen by immersion in dry ice/hexane at 3, 9, 24 h and 3 d. At 3 h, high concentrations of radioactivity were observed in salivary gland, bile, kidney, urine, and gastrointestinal contents. A moderate level of radioactivity was seen in the blood, lung, spleen, esophagus, liver, oral cavity and aortic wall. In 9-24 h, remarkable accumulations of radioactivity were found in salivary glands and gastric mucosa and contents. The intense localization of 14C in salivary gland and gastric mucosa and less retention in gastric contents persisted throughout the entire period of 3d.