Original Article

Effects of dimercaptosuccinic acid on binding of mercury with protein in rats

You-yi LIANG, Bai-yong MAO, Jian-shi ZHANG, Zheng-qin TAO, Guang-sheng DING


After the rats were injected im 10 μCi203HgCl2(0.13-1.4mg Hg/kg), the Hg in setum was almost entirely bound to the protein of high mol wt. In liver and kidneys, the Hg was mainly bound to the proteins of both high and medium mol wt forming 2 different types of Hg-protein complexes. Some high mol wl complexes appeared in urine. In the rats were treated with dimercaptosuccinic acid(DMSA), the contents of bound Hg with the proteins in serum, liver and kidneys were markedly reduced. The urinary excretion of Hg was greatly augmented in the form of “deffusible” complexes. The tissue-bound Hg was transferred into low mol wl diffusible Hg-complexes which were found chiefly in urine. Hence the transfer of Hg from the complex with proteins of high mol wl to low wl Hg-complexes by competitive binding of DMSA is the essential mechamism of DMSA detoxication in treatment of Hg poisoning.

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