Original Articles

Adaptive effect and withdrawal syndrome of propranolol in relation to norepinephrine and epinephrine

Authors: De-zai Dai, Jin-zhou Xie, Chun-fang Liu, Zhen-nan Wang


Two distinct phases of changes in the urinary and myocardial norepinephrine (NE) were observed in rats after sc injection of propranolol * 7d. The first phase was up-regulation of NE. The second phase was down-regulation of NE and designated as an adaptive effect which may be related to its antihypertensive effect. No adaptive effect on urinary E during medication was found. After withdrawal there was a significant rebound in NE and E, which might be the cause to lead to coronary accident in patients with severe ischaemic heart disease by acting on the hypersensitive beta-receptor in myocardium.

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