Effects of glycolate esters on conditioned behavior

Effects of QNB and 4-(3,5)-exo-cyclopropyl-N-methyl-piperidyl diphenyl hydroxyl acetate(B-7601) on avoidance conditioning and discrimination learning were studied in rats. After intraventricular injection of QNB and B-7601 with 3 dosages(20,30 and 40 microg) respectively, the % of correct responses decreased in performance of avoidance conditioning as well as in discrimination learning. But the minimal effective dose on performance of avoidance conditioning was lower than that on discrimination learning. Besides, it seems that the potency of anti-oxotremorine effects of these glycolate esters do not correlate with that of their effects on conditioned behavior.